Skip to main content

Table 3 Geometric mean estradiol (pg/ml), estrone (pg/ml), and testosterone (ng/dl) concentrations by genotype among postmenopausal Caucasian and Asian women with breast cancer in Washington state

From: UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients

Genotype Estradiol Estrone Testosterone
  n Geometric
meana
(95% CI)
Percentage
difference (P)
n Geometric
meana
(95% CI)
Percentage
difference (P)
n Geometric
meana
(95% CI)
Percentage
difference (P)
UGT1A1          
   (TA)6/(TA)6 (wt) 47 10.5
(9.1–12.1)
(Reference) 47 23.4
(20.9–26.3)
(Reference) 46 27.8
(24.9–31.0)
(Reference)
   (TA)6/(TA)7 (het) 36 9.0
(7.3–11.2)
-14.1 (0.26) 36 21.1
(17.8–24.9)
-10.1 (0.31) 36 27.2
(23.8–31.2)
-1.9 (0.83)
   (TA)7/(TA)7 (var) 4 16.6
(12.3–22.4)
+58.0 (0.01) 4 33.8
(19.9–57.4)
+44.1 (0.18) 4 29.9
(23.4–38.1)
+7.5 (0.60)
UGT2B4          
   Asp/Asp (wt) 51 9.5
(8.2–11.1)
(Reference) 51 22.3
(19.4–25.6)
(Reference) 50 27.3
(24.5–30.4)
(Reference)
   Asp/Glu (het) 29 11.0
(8.9–13.5)
+15.3 (0.29) 29 23.4
(19.6–28.1)
+5.2 (0.67) 29 28.5
(24.6–33.0)
+4.3 (0.67)
   Glu/Glu (var) 7 10.9
(7.3–16.2)
+14.4 (0.53) 7 24.3
(18.2–32.5)
+9.2 (0.59) 7 26.6
(19.9–35.4)
-2.8 (0.86)
UGT2B7          
   His/His (wt) 24 9.8
(7.5–12.8)
(Reference) 24 21.5
(17.8–26.0)
(Reference) 24 26.9
(23.3–31.0)
(Reference)
   His/Tyr (het) 48 11.1
(9.6–12.9)
+13.3 (0.42) 48 24.0
(21.2–27.2)
+11.5 (0.34) 48 29.1
(26.2–32.3)
+8.2 (0.37)
   Tyr/Tyr (var) 15 7.8
(5.6–10.7)
-20.9 (0.31) 15 21.3
(16.1–28.3)
-0.9 (0.96) 14 24.4
(19.4–30.7)
-9.2 (0.51)
UGT2B15          
   Asp/Asp (wt) 19 7.2
(5.6–9.3)
(Reference) 19 20.7
(16.1–26.5)
(Reference) 18 26.8
(21.3–33.6)
(Reference)
   Asp/Tyr (het) 45 11.5
(9.9–13.3)
+58.7 (0.003) 45 23.7
(20.9–26.8)
+14.6 (0.34) 45 29.0
(26.1–32.2)
+8.3 (0.55)
   Tyr/Tyr (var) 23 10.4
(8.2–13.1)
+43.7 (0.05) 23 23.1
(18.3–29.0)
+11.6 (0.53) 23 25.8
(22.0–30.3)
-3.6 (0.78)
SULT1A1          
   Arg/Arg (wt) 37 9.9
(7.8–12.6)
(Reference) 37 24.1
(20.0–29.2)
(Reference) 37 27.7
(23.9–32.0)
(Reference)
   Arg/His (het) 38 9.8
(8.3–11.6)
-1.5 (0.93) 38 21.3
(18.6–24.3)
-12.0 (0.30) 37 25.2
(22.7–27.9)
-9.0 (0.32)
   His/His (var) 12 11.6
(8.8–15.4)
+17.2 (0.42) 12 24.0
(19.3–29.9)
-0.6 (0.97) 12 36.5
(30.3–44.0)
+32.0 (0.03)
  1. CI, confidence interval; het, heterozygous; var, homozygous variant; wt, wild-type. aGeometric mean estimates are for an individual with mean values of all covariates; adjusted for age, use of tamoxifen at the time of blood draw, smoking, alcohol use, percentage body fat, batch (estrone and estradiol only), number of ovaries remaining, and race (Asian/Caucasian).