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Table 3 Geometric mean estradiol (pg/ml), estrone (pg/ml), and testosterone (ng/dl) concentrations by genotype among postmenopausal Caucasian and Asian women with breast cancer in Washington state

From: UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients

Genotype

Estradiol

Estrone

Testosterone

 

n

Geometric

meana

(95% CI)

Percentage

difference (P)

n

Geometric

meana

(95% CI)

Percentage

difference (P)

n

Geometric

meana

(95% CI)

Percentage

difference (P)

UGT1A1

         

   (TA)6/(TA)6 (wt)

47

10.5

(9.1–12.1)

(Reference)

47

23.4

(20.9–26.3)

(Reference)

46

27.8

(24.9–31.0)

(Reference)

   (TA)6/(TA)7 (het)

36

9.0

(7.3–11.2)

-14.1 (0.26)

36

21.1

(17.8–24.9)

-10.1 (0.31)

36

27.2

(23.8–31.2)

-1.9 (0.83)

   (TA)7/(TA)7 (var)

4

16.6

(12.3–22.4)

+58.0 (0.01)

4

33.8

(19.9–57.4)

+44.1 (0.18)

4

29.9

(23.4–38.1)

+7.5 (0.60)

UGT2B4

         

   Asp/Asp (wt)

51

9.5

(8.2–11.1)

(Reference)

51

22.3

(19.4–25.6)

(Reference)

50

27.3

(24.5–30.4)

(Reference)

   Asp/Glu (het)

29

11.0

(8.9–13.5)

+15.3 (0.29)

29

23.4

(19.6–28.1)

+5.2 (0.67)

29

28.5

(24.6–33.0)

+4.3 (0.67)

   Glu/Glu (var)

7

10.9

(7.3–16.2)

+14.4 (0.53)

7

24.3

(18.2–32.5)

+9.2 (0.59)

7

26.6

(19.9–35.4)

-2.8 (0.86)

UGT2B7

         

   His/His (wt)

24

9.8

(7.5–12.8)

(Reference)

24

21.5

(17.8–26.0)

(Reference)

24

26.9

(23.3–31.0)

(Reference)

   His/Tyr (het)

48

11.1

(9.6–12.9)

+13.3 (0.42)

48

24.0

(21.2–27.2)

+11.5 (0.34)

48

29.1

(26.2–32.3)

+8.2 (0.37)

   Tyr/Tyr (var)

15

7.8

(5.6–10.7)

-20.9 (0.31)

15

21.3

(16.1–28.3)

-0.9 (0.96)

14

24.4

(19.4–30.7)

-9.2 (0.51)

UGT2B15

         

   Asp/Asp (wt)

19

7.2

(5.6–9.3)

(Reference)

19

20.7

(16.1–26.5)

(Reference)

18

26.8

(21.3–33.6)

(Reference)

   Asp/Tyr (het)

45

11.5

(9.9–13.3)

+58.7 (0.003)

45

23.7

(20.9–26.8)

+14.6 (0.34)

45

29.0

(26.1–32.2)

+8.3 (0.55)

   Tyr/Tyr (var)

23

10.4

(8.2–13.1)

+43.7 (0.05)

23

23.1

(18.3–29.0)

+11.6 (0.53)

23

25.8

(22.0–30.3)

-3.6 (0.78)

SULT1A1

         

   Arg/Arg (wt)

37

9.9

(7.8–12.6)

(Reference)

37

24.1

(20.0–29.2)

(Reference)

37

27.7

(23.9–32.0)

(Reference)

   Arg/His (het)

38

9.8

(8.3–11.6)

-1.5 (0.93)

38

21.3

(18.6–24.3)

-12.0 (0.30)

37

25.2

(22.7–27.9)

-9.0 (0.32)

   His/His (var)

12

11.6

(8.8–15.4)

+17.2 (0.42)

12

24.0

(19.3–29.9)

-0.6 (0.97)

12

36.5

(30.3–44.0)

+32.0 (0.03)

  1. CI, confidence interval; het, heterozygous; var, homozygous variant; wt, wild-type. aGeometric mean estimates are for an individual with mean values of all covariates; adjusted for age, use of tamoxifen at the time of blood draw, smoking, alcohol use, percentage body fat, batch (estrone and estradiol only), number of ovaries remaining, and race (Asian/Caucasian).
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Breast Cancer Research

ISSN: 1465-542X

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