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Table 2 Mammary carcinogenesis in N-methyl-N-nitrosourea injected rats

From: Insulin-like growth factor (IGF)-I obliterates the pregnancy-associated protection against mammary carcinogenesis in rats: evidence that IGF-I enhances cancer progression through estrogen receptor-α activation via the mitogen-activated protein kinase pathway

Groups Cancer incidence (%) Cancer load number/rat (mean ± SEM) Latency range (days)
P-UN (n = 6) 16* 0.167 121
P-IGF-I (n = 6) 83 2.17 ± 0.75 57–176
AMV (n = 6) 100 2.20 ± 0.45 92–217
  1. Mammary tumor incidence, latency, and load in untreated parous rats (P-Un), parous rats treated with insulin-like growth factor -I, and in virgin rats that were age matched with the parous animals (AMV). *P < 0.05 versus P-IGF-I and AMV.