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Table 5 P values from single genotype and haplotype association tests

From: Oestrogen receptor α gene haplotype and postmenopausal breast cancer risk: a case control study

SNP/haplotype tested

Unadjusted

Adjusted for multiple testing

dfa

 

Control v. ductal

Control v. lobular

Control v. ductal

 

Single loci

    

   c.454-397C→T

0.154

0.458

0.157

2

   c.454-351A→G

0.128

0.292

0.235

2

   c.729C→T

0.524

0.440

-b

2

   c.975C→G

0.037

0.845

0.106

2

Two-locus haplotypes

    

   c.454-397C→T and c.454-351A→G

0.152

0.918

0.219

3

   c.454-397C→T and c.975C→G

0.019

0.921

0.071

3

   c.454-351A→G and c.975C→G

0.022

0.930

0.077

3

Three-locus haplotype

    

   c.454-397C→T and c.454-351A→G and c.975C→G

0.097

0.995

0.178

7

  1. aDegrees of freedom. Genotype and haplotype frequency distributions are compared between cases and controls without prior assumptions about high-risk or low-risk genotypes or haplotypes. bExcluded from adjustments for multiple testing because of low allele frequency (see the text).