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Table 5 P values from single genotype and haplotype association tests

From: Oestrogen receptor α gene haplotype and postmenopausal breast cancer risk: a case control study

SNP/haplotype tested Unadjusted Adjusted for multiple testing dfa
  Control v. ductal Control v. lobular Control v. ductal  
Single loci     
   c.454-397C→T 0.154 0.458 0.157 2
   c.454-351A→G 0.128 0.292 0.235 2
   c.729C→T 0.524 0.440 -b 2
   c.975C→G 0.037 0.845 0.106 2
Two-locus haplotypes     
   c.454-397C→T and c.454-351A→G 0.152 0.918 0.219 3
   c.454-397C→T and c.975C→G 0.019 0.921 0.071 3
   c.454-351A→G and c.975C→G 0.022 0.930 0.077 3
Three-locus haplotype     
   c.454-397C→T and c.454-351A→G and c.975C→G 0.097 0.995 0.178 7
  1. aDegrees of freedom. Genotype and haplotype frequency distributions are compared between cases and controls without prior assumptions about high-risk or low-risk genotypes or haplotypes. bExcluded from adjustments for multiple testing because of low allele frequency (see the text).