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Table 2 Odds ratios for ductal and lobular breast cancer in relation to single locus genotype

From: Oestrogen receptor α gene haplotype and postmenopausal breast cancer risk: a case control study

Genotypea 00 01 11 P HWE c
Polymorphism Cases/Controls ORb 95% CI Cases/Controls ORb 95% CI Cases/Controls ORb 95% CI  
Promoter TA n           
   Ductal 369/445 1 Ref 494/593 1.01 0.84–1.21 230/312 0.87 0.70–1.09 <0.001, <0.0001d
   Lobular 52/445 1 Ref 81/593 1.30 0.88–1.91 33/212 0.92 0.57–1.49  
Intron 1 c.454-397C→T           
   Ductal 347/384 1 Ref 542/651 0.93 0.77–1.12 229/313 0.80 0.64–1.01 0.32
   Lobular 43/384 1 Ref 92/651 1.42 0.95–2.11 39/313 1.18 0.73–1.90  
Intron 1 c.454-351A→G           
   Ductal 522/577 1 Ref 471/610 0.86 0.72–1.02 124/161 0.86 0.66–1.12 0.88
   Lobular 66/577 1 Ref 89/610 1.36 0.96–1.92 19/161 1.05 0.60–1.84  
Exon 3 c.729C→T           
   Ductal 1037/1253 1 Ref 84/93 1.07 0.78–1.45 1/3 0.41 0.04–4.00 0.20
   Lobular 164/1253 1 Ref 10/93 0.92 0.46–1.83 0/3 - -  
Exon 4 c.975C→G           
   Ductal 722/805 1 Ref 346/477 0.81 0.68–0.96 54/67 0.93 0.64–1.35 0.87
   Lobular 106/805 1 Ref 59/477 0.94 0.66–1.34 9/67 1.00 0.48–2.10  
  1. OR, odds ratio. aThe genotypes are as follows: TA n , 00 ≤ 14/≤ 14, 01 ≤ 14/>14, 11 >14/>14; c.454-397C → T, 00 T/T, 01 T/C, 11 C/C; c.454-351A → G, 00 A/A, 01 A/G, 11 G/G; c.729C → T, 00 C/C, 01 C/T, 11 T/T; c.975C → G, 00 C/C, 01 C/G, 11 G/G. bLong-term users of menopausal hormones and diabetics were oversampled; thus, logistic regression models are adjusted for age and sampling category, which means that only those with complete information about hormone use and diabetes mellitus were included. c P value for χ2 test of deviation from the assumption of Hardy–Weinberg equilibrium, among controls only. dFor this test for deviation from Hardy–Weinberg equilibrium either all microsatellite alleles were considered or lengths were categorised into ≤10, 11, 12 or 13, 14–16, 17, 18, 19, or ≥ 20.