From: Oestrogen receptor α gene haplotype and postmenopausal breast cancer risk: a case control study
Genotypea | 00 | 01 | 11 | P HWE c | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Polymorphism | Cases/Controls | ORb | 95% CI | Cases/Controls | ORb | 95% CI | Cases/Controls | ORb | 95% CI | |
Promoter TA n | ||||||||||
Ductal | 369/445 | 1 | Ref | 494/593 | 1.01 | 0.84–1.21 | 230/312 | 0.87 | 0.70–1.09 | <0.001, <0.0001d |
Lobular | 52/445 | 1 | Ref | 81/593 | 1.30 | 0.88–1.91 | 33/212 | 0.92 | 0.57–1.49 | |
Intron 1 c.454-397C→T | ||||||||||
Ductal | 347/384 | 1 | Ref | 542/651 | 0.93 | 0.77–1.12 | 229/313 | 0.80 | 0.64–1.01 | 0.32 |
Lobular | 43/384 | 1 | Ref | 92/651 | 1.42 | 0.95–2.11 | 39/313 | 1.18 | 0.73–1.90 | |
Intron 1 c.454-351A→G | ||||||||||
Ductal | 522/577 | 1 | Ref | 471/610 | 0.86 | 0.72–1.02 | 124/161 | 0.86 | 0.66–1.12 | 0.88 |
Lobular | 66/577 | 1 | Ref | 89/610 | 1.36 | 0.96–1.92 | 19/161 | 1.05 | 0.60–1.84 | |
Exon 3 c.729C→T | ||||||||||
Ductal | 1037/1253 | 1 | Ref | 84/93 | 1.07 | 0.78–1.45 | 1/3 | 0.41 | 0.04–4.00 | 0.20 |
Lobular | 164/1253 | 1 | Ref | 10/93 | 0.92 | 0.46–1.83 | 0/3 | - | - | |
Exon 4 c.975C→G | ||||||||||
Ductal | 722/805 | 1 | Ref | 346/477 | 0.81 | 0.68–0.96 | 54/67 | 0.93 | 0.64–1.35 | 0.87 |
Lobular | 106/805 | 1 | Ref | 59/477 | 0.94 | 0.66–1.34 | 9/67 | 1.00 | 0.48–2.10 |