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  1. Doctor must know both Oncological Terrain and Oncological "Real Risk" also in the war against Breast Cancer

    Sergio Stagnaro, Private

    6 June 2004


    more than half of people with, e.g., hepatocellular carcinoma (more than 500.000 cases globally annually with a five year mortality exceeding 95%) are notoriously in China. “The causes of most of these cancers are now known, and their prevention is possible” (1). Now a days we notoriously know a lot of gene mutation (like BRCA 1, BRCA 2, a.s.o.)in females involved by breast cancer. At this points, my first question: “In whom hepatocellular carcinoma, and breast cancer primary prevention has to be performed? For instance, in “all” Chinese individuals or in all womens around the world?”. In additon, the same authors, in agreement with others, continue: “More than 50% of hepatocellular carcinomas are due to persistent (as opposed to transient) hepatitis B infection, and around 25% are due to persistent hepatitis C virus”. It is plain that some, but “not all” subjects , who suffered from such as infectious viral disease, present hepatocellular carcinomas(75% of diseased subjects present HC: it is too much in my 46-year-long clinical experience!) Seemingly, not all women with BRCA1 and/or BCRA2 will suffer from breast cancer. Certainly, I agree with the autors who state that “Preventing infection (i.e., Hepatitis B vaccination, or brast cancer with either these two hepatitis viruses or mutated genes)is one key strategy to reduce the burden of liver as well as breast cancer cancer”.

    However, I like to put my third, and least, but not last, question: “Who must undergo to hepatitis – B, C – vaccination in order to prevent cancer? And who, MALEs and females. must undergo to examination for BRCA1 and BRCA2?” In my opinion, Primary Prevention of the most common and dangerous human pathologies, including breast cancer, depends mainly by easy and quick bed-side detecting individuals at "real" risk, e.g., of cancer (See my HONCode 233736, website, Oncological Terrain, Oncogenesis, three articles: Biophysical-Semeiotic Constitutions) (2, 3, 4, 5). To define clinically a particular constitution, which does not exclude the presence of others, it is necessary to think over the current possibility of gathering at the bed-side "biophysical-semeiotic" data, providing biological and molecular-biological information on the various human organs, tissues and apparatus, so that doctor can describe numerous types of constitutions, even from the quantitative point of view. Without any doubt, these data can not be observed at all by the aid of traditional physic semeiotics, unable of carrying molecular-biological events to clincal dimension, which really represents the most original and fertile aspect of Biophysical Semeiotics. In conclusion, we must recognize, at first, individual involved by “Oncological Terrain”, i.e., “Oncological Constitution” (5), and then localized precisely the real risk of cancer in a quantitative way, so that the prevention can be perform in individuals clinically (i.e., on very large scale) and rationally selected, regardless of the level of country incomes.

    Sergio Stagnaro MD.,Member NYAS.

    1) Hall AJ., Wild CP.Liver cancer in low and middle income countries Prevention should target vaccination, contaminated needles, and aflatoxins BMJ 2003;326:994-995 ( 10 May ).

    2) Stagnaro-Neri M., Stagnaro S. Cancro della Mammella: Prevenzione Primaria e Diagnosi clinica precoce con la Percussione Ascolata. Gazz. Med. It-Arch. Sci.Med. 152, 447-457, 1993.

    3) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica condizione necessaria non sufficiente della oncogenesi. XI Congr. Naz. Soc. It. di Microangiologia e Microcircolaz. Abstracts, pg 38, 28 Settembre-1 Ottobre, Bellagio,1983

    4) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. Una Patologia Mitocondriale Ignorata. Gazz Med. It. – Arch. Sci. Med. 144, 423, 1985 (Infotrieve)

    5)Stagnaro-Neri Marina, Stagnaro Sergio. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Travel Factory SRL., Roma, 2004.

    Competing interests

    No declared