Skip to main content

Table 1 DNMT3B genotype frequencies of breast cancer cases and controls

From: The DNMT3B C→T promoter polymorphism and risk of breast cancer in a British population: a case-control study

Group No. of subjects TT No. (%) TC No. (%) P a OR (95% CI) CC No. (%) P a OR (95% CI) TC+CC No. (%) P a (OR, 95% CI)
Control 258 60 (23.3) 116 (45.0)    82 (31.8)    198 (76.8)   
All breast cancer 352 59 (16.8) 173 (49.1) 0.06 1.52 (0.99–2.33) 120 (34.1) 0.10 1.49 (0.94–2.35) 293 (83.2) 0.05 1.51 (1.01–2.25)
Under 40b 212 34 (16.0) 103 (48.6) 0.08 1.57 (0.95–2.58) 75 (35.4) 0.09 1.61 (0.96–2.73) 178 (84.0) 0.06 1.21 (1.01–1.45)
Family history bilateral cancerc 245 46 (18.5) 119 (47.8) 0.24 1.34 (0.84–2.12) 84 (33.7) 0.26 1.34 (0.82–2.18) 203 (81.5) 0.19 1.34 (0.87–2.06)
  1. OR, odds ratio; CI, 95% confidence interval. a P was determined by Fisher's exact test (two-sided) for the relevant genotype, with the TT homozygotes as reference. bThis group includes cases that were originally selected on the basis of family history but where the diagnosis was made earlier than 40 years of age. cThis group includes cases that were originally selected on the basis of diagnosis earlier than 40 years of age but where there was also bilateral disease or a family history of cancer.
\