Table 3 CYP1A2 activity and risk factors for breast cancer: premenopausal women

Age (years)

0.001 (0.007)

0.01

0.93

Age at first birth (years)²

0.16 (0.21)

0.56

0.46

Age at menarche (years)

0.03 (0.03)

1.80

0.18

6.11 (5.12–7.29)

6.55 (5.49–7.81)

7.39 (5.84–9.35)

6.62 (5.03–8.71)

0.16

BMI (kg/m²)²

-0.43 (0.19)

5.05

0.03

7.76 (6.32–9.53)

6.11 (5.09–7.33)

6.17 (5.02–7.57)

6.16 (4.89–7.76)

0.04

WHR

1.26 (0.70)

3.23

0.07

5.89 (4.80–7.24)

6.01 (4.90–7.37)

6.46 (5.31–7.86)

7.20 (5.87–8.83)

0.06

Caffeine (mg/day)¹

0.020 (0.007)

6.32

0.01

5.42 (4.49–6.54)

6.37 (5.29–7.68)

6.28 (5.17–7.64)

6.94 (5.84–8.24)

0.02

Alcohol (kcal/day)²

0.03 (0.02)

2.13

0.15

5.17 (4.33–6.16)

5.17 (4.29–6.23)

5.88 (4.85–7.12)

6.12 (5.03–7.45)

0.05

Cholesterol (mg/day)²

0.09 (0.08)

1.29

0.26

Total energy (kcal/day)¹

0.01 (0.01)

6.05

0.02

5.73 (4.70–6.98)

6.18 (5.00–7.64)

6.58 (5.46–7.93)

6.81 (5.56–8.33)

0.06

Carbohydrate (g/day)¹

0.02 (0.02)

2.26

0.14

5.87 (4.84–7.13)

6.75 (5.51–8.26)

6.30 (5.13–7.74)

6.63 (5.45–8.07)

0.34

Fat intake (g/day)¹

0.05 (0.02)

4.33

0.04

6.04 (5.20–7.01)

6.94 (5.98–8.05)

6.38 (5.46–7.45)

7.01 (6.03–8.15)

0.25

Protein intake (g/day)²

0.29 (0.11)

7.81

0.006

6.01 (4.97–7.27)

6.74 (5.45–8.33)

6.20 (5.08–7.55)

6.93 (5.65–8.50)

0.28

Total estradiol (pmol/l)³

-0.001 (0.006)

0.01

0.92

Free estradiol (%)²

-0.05 (0.01)

11.02

0.001

6.62 (5.51–7.96)

7.46 (6.16–9.04)

5.99 (4.90–7.31)

5.16 (4.19–6.35)

0.007

SHBG (nmol/l)⁴

0.07 (0.02)

10.89

0.001

5.13 (4.16–6.35)

6.09 (4.96–7.46)

7.57 (6.17–9.28)

6.73 (5.64–8.03)

0.004

Progesterone (nmol/l)¹

-0.01 (0.02)

0.40

0.53

FSH (IU/l)²

0.01 (0.04)

0.01

0.91

GH (μg/l)⁵

0.01 (0.03)

0.14

0.71

IGF-1 (ng/ml)⁶

0.30 (0.22)

1.73

0.19

5.59 (4.59–6.81)

6.59 (5.38–8.06)

7.63 (6.19–9.41)

6.75 (5.41–8.43)

0.07

IGFBP-3 (mg/l)⁷

-0.14 (0.31)

0.20

0.66

Insulin (pmol/l)²

0.24 (0.09)

6.91

0.01

5.44 (4.51–6.57)

5.52 (4.49–6.78)

7.16 (5.91–8.68)

7.61 (6.19–9.37)

0.0009

Total cholesterol (mmol/l)²

-0.74 (0.20)

13.84

0.0003

7.37 (5.93–9.17)

6.88 (5.71–8.28)

6.24 (5.14–7.58)

5.64 (4.62–6.89)

0.006

LDL-cholesterol (mmol/l)²

-0.44 (0.15)

8.82

0.004

7.28 (5.91–8.96)

6.77 (5.60–8.19)

6.67 (5.54–8.04)

5.24 (4.30–6.39)

0.004

HDL-cholesterol (mmol/l)²

-0.27 (0.15)

3.35

0.07

7.05 (5.76–8.63)

6.17 (5.06–7.52)

6.83 (5.60–8.32)

5.83 (4.79–7.09)

0.11

Triglycerides (mmol/l)²

-0.02 (0.07)

0.04

0.83