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Table 2 Selected characteristics of study subjects by ethnicity: postmenopausal women

From: Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study

  With CYP1A2 results No CYP1A2 results5 (n = 26)
  Caucasian1 (n = 126) East Asian2 (n = 6) Jewish3 (n = 5) Other4 (n = 12)  
Risk factors      
   Age (years) 56.3 (4.6) 54.8 (3.8) 53.4 (2.5) 55.9 (4.2) 56.0 (4.5)
   Weight (kg) 72.5 (16.6) 55.8 (9.8) 70.5 (18.1) 66.6 (15.7) 63.7 (17.0)
   BMI (kg/m2) 26.8 (6.2) 23.2 (4.7) 25.9 (6.8) 25.6 (5.4) 23.3 (5.2)
   WHR 0.77 (0.07) 0.77 (0.08) 0.80 (0.09) 0.80 (0.06) 0.75 (0.11)
   Age at menarche (years) 13.1 (1.6) 13.0 (1.7) 12.6 (2.6) 13.0 (2.1) 12.8 (1.7)
   Age at menopause (years) 49.1 (4.8) 50.8 (3.3) 49.1 (3.7) 48.8 (2.5) 48.2 (4.3)
   Age at first birth (years) 26.0 (5.2) 34.6 (6.8) 22.8 (3.8) 31.0 (8.7) 25.4 (4.1)
   Number of live births 1.8 (1.5) 1.8 (1.5) 2.2 (1.6) 1.0 (1.0) 1.3 (1.4)
   Mammographic density (%)6 19.8 (18.5) 48.2 (8.9) 22.3 (24.6) 30.1 (23.8) 36.0 (22.1)
   CYP1A2 activity (CMR)7 5.7 (2.2) 8.9 (1.8) 3.5 (1.7) 6.6 (2.8) -
Hormones      
   Estradiol (pmol/l) 44.6 (91.1) 31.8 (14.3) 27.9 (10.6) 51.1 (33.4) 72.6 (117.5)
   Free estradiol (%) 2.6 (0.6) 2.4 (0.5) 2.4 (0.6) 2.7 (0.4) 2.2 (0.7)
   SHBG (nmol/l) 41.0 (22.2) 47.8 (16.8) 47.6 (22.3) 36.9 (14.8) 54.2 (26.5)
   IGF-1 (ng/ml) 127.8 (33.0) 126.7 (42.6) 137.0 (34.7) 137.3 (36.6) 139.3 (37.5)
   IGFBP-3 (mg/l) 2.8 (0.5) 2.6 (0.4) 3.0 (0.5) 2.8 (0.4) 2.8 (0.6)
   Insulin (pmol/l) 77.1 (46.4) 78.6 (46.7) 91.3 (40.1) 103.7 (53.9) 75.9 (52.9)
Nutritional variables      
   Caffeine intake (mg/day) 193.0 (117.3) 179.0 (147.6) 93.0 (59.4) 118.5 (73.2) 9.0 (9.7)
   Total energy intake (kcal/day) 1779.7 (491.1) 1884.7 (646.4) 1234.3 (215.3) 1579.8 (274.3) 1648.0 (523.3)
Blood lipids      
   Total cholesterol (mmol/l) 5.6 (0.8) 5.7 (0.7) 5.4 (1.0) 5.6 (0.9) 5.2 (1.1)
   Triglycerides (mmol/l) 1.5 (0.8) 1.4 (0.8) 1.8 (0.9) 1.4 (0.6) 1.2 (0.5)
  1. Values are expressed as mean (standard deviation). 1 n = 117 for age at menopause; n = 97 for age at first birth; n = 105 for total estradiol; and n = 125 for free estradiol, insulin-like growth factor (IGF-1), and IGF binding protein (IGFBP)-3. 2 n = 5 for age at first birth, free estradiol, and sex hormone binding globulin (SHBG). 3 n = 4 for age at first birth. 4 n = 11 for menopausal age and total estradiol and n = 8 for age at first birth. 5 n = 23 for menopausal age, n = 14 for age at first birth, n = 22 for total estradiol, and n = 15 for caffeine. 6Proportion of breast area occupied by dense tissue. 7Estimated by caffeine metabolic ratio (CMR; see text for details). BMI, body mass index; WHR, waist–hip ratio.
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