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Table 3 Joint effects of the manganese superoxide dismutase (MnSOD) genotype and environmental risk factors on breast cancer

From: Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case–control study of African Americans and whites

 

Val/Val or Val/Ala MnSOD genotype

Ala/Ala MnSOD genotype

 
 

Cases/controls

Odds ratio (95% CI)

Cases/controls

Odds ratio (95% CI)

ICR (95% CI)

Vitamin usea

     

   No vitamin use

626/543

Referent

148/143

0.9 (0.7–1.2)

 

   Any vitamin use

959/862

0.9 (0.8–1.1)

292/264

0.9 (0.7–1.1)

0.1 (-0.2, 0.4)

   Multivitamin use

791/695

1.0 (0.8–1.1)

235/200

0.9 (0.7–1.2)

0.1 (-0.2, 0.4)

   Vitamin A

58/48

1.1 (0.7–1.7)

17/16

0.9 (0.4–1.9)

-0.1 (-1.0, 0.7)

   Vitamin C

405/363

1.0 (0.8–1.2)

129/103

1.1 (0.8–1.5)

0.3 (-0.1, 0.7)

   Vitamin E

401/325

1.1 (0.9–1.3)

123/101

1.1 (0.8–1.5)

0.1 (-0.3, 0.6)

   Beta-carotene

59/58

1.0 (0.7–1.6)

17/15

1.1 (0.5–2.4)

0.2 (-0.8, 1.1)

   Calcium supplements

413/412

0.8 (0.7–1.0)

137/123

0.9 (0.7–1.3)

0.2 (-0.2, 0.6)

Smokingb

     

   No active or passive

311/268

Referent

87/87

0.8 (0.6–1.2)

 

   Passive only

540/478

1.0 (0.8–1.3)

143/144

1.0 (0.7–1.3)

 

   Duration of active smoking

     

≤10 years

186/180

0.9 (0.7–1.3)

59/56

0.9 (0.6–1.3)

 

>10 years to 20 years

175/166

1.0 (0.8–1.4)

52/49

0.8 (0.6–1.4)

 

>20 years

366/309

1.2 (0.9–1.5)

96/71

1.5 (1.0–2.2)

0.5 (-0.1, 1.0)

Alcohol consumptionc

     

   No

507/454

Referent

122/139

0.7 (0.6–1.0)

 

   Yes

1076/949

1.0 (0.8–1.2)

318/268

1.0 (0.8–1.3)

0.3 (0.0, 0.6)

High-dose radiation to chesta

     

   No

1468/1299

Referent

395/387

0.9 (0.8–1.1)

 

   Yes

116/106

1.1 (0.8–1.4)

45/20

2.3 (1.3–4.1)

1.3 (0.0, 2.7)

Occupational exposure to ionizing radiationa

     

   No

1497/1334

Referent

413/391

0.9 (0.8–1.1)

 

   Yes

88/71

1.1 (0.8–1.6)

27/16

1.6 (0.8–3.1)

0.6 (-0.5, 1.7)

Oral contraceptives (regular use)a

     

   No

561/511

Referent

136/146

0.9 (0.6–1.1)

 

   Yes

1016/885

1.1 (0.9–1.4)

304/258

1.1 (0.9–1.4)

0.1 (-0.2, 0.5)

Hormone replacement therapy (postmenopausal women, regular use)a

     

   No

436/375

Referent

117/106

1.0 (0.7–1.3)

 

   Yes

446/426

0.8 (0.7–1.0)

122/122

0.7 (0.5–1.0)

-0.1 (-0.5, 0.3)

  1. CI, confidence interval; ICR, interaction contrast ratio. a Adjusted for offsets, age, race, family history, age at menarche, age at first full-term pregnancy (AFFTP)/parity composite, smoking duration, and alcohol use. b Adjusted for offsets, age, race, family history, age at menarche, AFFTP/parity composite, and alcohol use. c Adjusted for offsets, age, race, family history, age at menarche, AFFTP/parity composite, and smoking duration.
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Breast Cancer Research

ISSN: 1465-542X

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