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Table 5 Relationships between mRNA values of the seven selected genes and the ERα gene in the 97 estrogen receptor alpha (ERα)-positive breast tumor series

From: Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma

  CYP2B6 FMO5 NAT1 SULT2B1 GSTM3 ABCC11 ESR1/ERα
CYP2A6 + 0.471 [< 0.001] + 0.171 [NS (0.091)] + 0.248 [0.014] + 0.084 [NS (0.42)] -0.037 [NS (0.72)] -0.173 [NS (0.086)] + 0.281 [0.0053]
CYP2B6   + 0.525 [< 0.001] + 0.433 [< 0.001] + 0.083 [NS (0.42)] + 0.022 [NS (0.83)] + 0.022 [NS (0.82)] + 0.409 [< 0.001]
FMO5    + 0.420 [< 0.001] -0.099 [NS (0.34)] -0.008 [NS (0.93)] + 0.216 [0.032] + 0.316 [0.0018]
NAT1     + 0.077 [NS (0.46)] + 0.104 [NS (0.31)] + 0.041 [NS (0.69)] + 0.293 [0.0037]
SULT2B1      + 0.232 [0.021] + 0.049 [NS (0.64)] + 0.091 [NS (0.38)]
GSTM3       + 0.198 [0.049] + 0.239 [0.018]
ABCC11        + 0.023 [NS (0.82)]
  1. Data presented as Spearman rank correlation coefficient [P value (Spearman rank correlation test)]. NS, not significant.