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Table 4 Estimated risk for lymph node metastasis with estrogen receptor-α genotypes

From: Estrogen receptor-α polymorphism in a Taiwanese clinical breast cancer population: a case–control study

  LN metastasis (n= 156)   
Genotype Absent (n = 92) Present (n = 64) P OR (95% CI)
Single site     
   Codon 10a     
00 44 (54%) 37 (46%)   1.0 (reference)
01 35 (63%) 21 (37%) 0.194 0.7 (0.36–1.43)
11 13 (68%) 6 (32%)   0.6 (0.19–1.59)
   Codon 325b     
00 16 (50%) 16 (50%)   1.0 (reference)
01 43 (53%) 38 (47%) 0.013 0.9 (0.39–2.00)
11 33 (77%) 10 (23%)   0.3 (0.11–0.82)
   Codon 594c     
00 56 (53%) 49 (47%)   1.0 (reference)
01 32 (71%) 13 (29%) 0.062 0.5 (0.22–0.98)
11 4 (67%) 2 (33%)   0.6 (0.10–3.26)
Dual sites     
   codon 325:codon 594     
00:00 12 (43%) 16 (57%)   1.00 (reference)
01:00 or 00:01 29 (49%) 30 (51%) 0.001 0.78 (0.31–1.92)
01:01 or 11:00 or 00:11 35 (71%) 14 (29%)   0.30 (0.11–0.79)
01:11 or 11:01 or 11:11 16 (80%) 4 (20%)   0.19 (0.05–0.71)
  1. aGenotype 00, TCT/TCT; genotype 01, TCT/TCC; genotype 11, TCC/TCC. bGenotype 00, CCC/CCC; genotype 01, CCC/CCG; genotype 11, CCG/CCG. cGenotype 00, ACG/ACG; genotype 01, ACG/ACA; genotype 11, ACA/ACA. LN, lymph node.
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