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Table 3 Genotypic and allelic frequencies of estrogen receptor-α in the Taiwanese population: breast cancer group versus control group and breast cancer cases in the presence versus the absence of a family history

From: Estrogen receptor-α polymorphism in a Taiwanese clinical breast cancer population: a case–control study

  ER-α genotypes ER-α
  00 01 11 0 1
Exon 1, codon 10 (TCT → TCC)a      
   Breast cancer χ2= 4.949, P = 0.026 χ2 = 5.566, P = 0.018
Cases (n = 189 subjects/378 alleles) 91 (48.1)d 75 (39.7) 23 (12.2) 257 (68.0) 121 (32.0)
Controls (n = 177 subjects/354 alleles) 69 (39.0) 73 (41.2) 35 (19.8) 211 (59.6) 143 (40.4)
   Family history in case group χ2= 0.387, P = 0.534 χ2 = 0.421, P= 0.517
Presence (n = 17 subjects/34 alleles) 12 (70.6) 1 (5.9) 4 (23.5) 25 (73.5) 9 (26.5)
Absence (n = 163 subjects/326 alleles) 76 (46.6) 70 (43.0) 17 (10.4) 222 (68.1) 104 (31.9)
Exon 4, codon 325 (CCC → CCG)b      
   Breast cancer χ2= 2.910, P = 0.088 χ2 = 2.723, P= 0.099
Cases (n = 189 subjects/378 alleles) 43 (22.7) 95 (50.3) 51 (27.0) 181 (47.9) 197 (52.1)
Controls (n = 177 subjects/354 alleles) 25 (14.1) 98 (55.4) 54 (30.5) 148 (41.8) 206 (58.2)
   Family history in case group χ2= 1.020, P = 0.312 χ2 = 1.055, P= 0.304
Presence (n = 17 subjects/34 alleles) 4 (23.5) 11 (64.7) 2 (11.8) 19 (55.9) 15 (44.1)
Absence (n = 163 subjects/326 alleles) 38 (23.3) 76 (46.6) 49 (30.1) 152 (46.6) 174 (53.4)
Exon 8, codon 594 (ACG → ACA)c      
   Breast cancer χ2= 0.003, P = 0.957 χ2 = 0.003, P= 0.956
Cases (n = 189 subjects/378 alleles) 128 (67.7) 52 (27.5) 9 (4.8) 308 (81.5) 70 (18.5)
Controls (n = 177 subjects/354 alleles) 117 (66.1) 55 (31.1) 5 (2.8) 289 (81.6) 65 (18.4)
   Family history in case group χ2= 3.605, P = 0.058 χ2 = 3.877, P= 0.049
Presence (n = 17 subjects/34 alleles) 15 (88.2) 2 (11.8) 0 (0.0) 32 (94.1) 2 (5.9)
Absence (n = 163 subjects/326 alleles) 107 (65.6) 48 (29.5) 8 (4.9) 262 (80.4) 64 (19.6)
  1. Data are expressed as n (%). aAllele 0, TCT; allele 1, TCC. bAllele 0, CCC; allele 1, CCG. cAllele 0, ACG; allele 1, ACA.
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