|
Exon 1, codon 10 (TCT → TCC)a
| | | | | |
|
Breast cancer
|
χ2= 4.949, P = 0.026
|
χ2 = 5.566, P = 0.018
|
|
Cases (n = 189 subjects/378 alleles)
|
91 (48.1)d
|
75 (39.7)
|
23 (12.2)
|
257 (68.0)
|
121 (32.0)
|
|
Controls (n = 177 subjects/354 alleles)
|
69 (39.0)
|
73 (41.2)
|
35 (19.8)
|
211 (59.6)
|
143 (40.4)
|
|
Family history in case group
|
χ2= 0.387, P = 0.534
|
χ2 = 0.421, P= 0.517
|
|
Presence (n = 17 subjects/34 alleles)
|
12 (70.6)
|
1 (5.9)
|
4 (23.5)
|
25 (73.5)
|
9 (26.5)
|
|
Absence (n = 163 subjects/326 alleles)
|
76 (46.6)
|
70 (43.0)
|
17 (10.4)
|
222 (68.1)
|
104 (31.9)
|
|
Exon 4, codon 325 (CCC → CCG)b
| | | | | |
|
Breast cancer
|
χ2= 2.910, P = 0.088
|
χ2 = 2.723, P= 0.099
|
|
Cases (n = 189 subjects/378 alleles)
|
43 (22.7)
|
95 (50.3)
|
51 (27.0)
|
181 (47.9)
|
197 (52.1)
|
|
Controls (n = 177 subjects/354 alleles)
|
25 (14.1)
|
98 (55.4)
|
54 (30.5)
|
148 (41.8)
|
206 (58.2)
|
|
Family history in case group
|
χ2= 1.020, P = 0.312
|
χ2 = 1.055, P= 0.304
|
|
Presence (n = 17 subjects/34 alleles)
|
4 (23.5)
|
11 (64.7)
|
2 (11.8)
|
19 (55.9)
|
15 (44.1)
|
|
Absence (n = 163 subjects/326 alleles)
|
38 (23.3)
|
76 (46.6)
|
49 (30.1)
|
152 (46.6)
|
174 (53.4)
|
|
Exon 8, codon 594 (ACG → ACA)c
| | | | | |
|
Breast cancer
|
χ2= 0.003, P = 0.957
|
χ2 = 0.003, P= 0.956
|
|
Cases (n = 189 subjects/378 alleles)
|
128 (67.7)
|
52 (27.5)
|
9 (4.8)
|
308 (81.5)
|
70 (18.5)
|
|
Controls (n = 177 subjects/354 alleles)
|
117 (66.1)
|
55 (31.1)
|
5 (2.8)
|
289 (81.6)
|
65 (18.4)
|
|
Family history in case group
|
χ2= 3.605, P = 0.058
|
χ2 = 3.877, P= 0.049
|
|
Presence (n = 17 subjects/34 alleles)
|
15 (88.2)
|
2 (11.8)
|
0 (0.0)
|
32 (94.1)
|
2 (5.9)
|
|
Absence (n = 163 subjects/326 alleles)
|
107 (65.6)
|
48 (29.5)
|
8 (4.9)
|
262 (80.4)
|
64 (19.6)
|
