Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Figure 3 | Breast Cancer Research

Figure 3

From: Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3

Figure 3

B-lymphocyte response during involution. (a) Pearson correlation clustering of immunoglobulin genes. The colours (see colour bar) represent a relative measure for the expression level, with 1 representing the median. Forty-nine immunoglobulin genes that were upregulated during involution were clustered by using the Pearson correlation clustering function from GeneSpring (Silicon Genetics); their average expression (red line) and standard deviations (blue lines) are shown in the graph on the right (DMT®; Affymetrix). Note that the y-axis represents only an arbitrary level of expression. Abbreviations: vir, virgin; preg, pregnancy; lac, lactation; inv, involution. (b) Cell count of plasma cells and B220+ B lymphocyes present in the mammary tissue during involution. Tissue sections were stained either with methyl green and pyronin or with an antibody against CD45R, and plasma cells and B lymphocytes were counted. Cell counts were taken from 20 high-power fields from each section in triplicate from three individual mice.

Back to article page