Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer

Table 2 Pearson correlation of the expression levels of mRNA coding for oestradiol metabolising enzymes

	CYP19	STS	HSD1	HSD2	EST	ERα	ERβ	ERBB2	Cyclin D₁
CYP19	1	0.081	-0.051	-0.054	0.021	-0.057	0.065	-0.071	-0.047
STS		1	0.333**	0.027	0.252**	0.045	0.274**	0.215**	0.195*
HSD1			1	-0.051	0.242**	0.107	0.047	0.003	0.164*
HSD2				1	-0.065	-0.144	0.050	-0.022	0.000
EST					1	0.550**	-0.082	0.089	0.422**
ERα						1	-0.089	-0.104	0.502**
ERβ							1	-0.031	-0.029
ERBB2								1	0.010
Cyclin D₁									1

Data presented as significance (two-tailed). CYP19, aromatase; STS, steroid sulfatase; HSD1, 17β-hydroxysteroid dehydrogenase I; HSD2, 17β-hydroxysteroid dehydrogenase II; EST, oestradiol sulfotransferase; ERα, oestrogen receptor α; ERβ, oestrogen receptor β. *Correlation significant at the 0.05 level (two-tailed). **Correlation significant at the 0.01 level (two-tailed).

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