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Figure 4 | Breast Cancer Research

Figure 4

From: Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE

Figure 4

Isolated and sequenced FGFR2 isoforms from SUM-52PE. IsolatedFGFR2 variants had variable expression of two to three Ig-like domains, as wellas the characteristic acid box in the extracellular portion of the molecule.Variability between isolated clones also existed in the intracellular portionof the molecule, where alternative splicing of exons C1/C2 or C3 created eithera full-length carboxyl termini (C1), or truncated versions (C2 or C3).

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