Cytoplasmic p21 WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis

Table 1 Clinicopathological variables according to c-erbB2 status

	HER-2-negative	HER-2-positive	P	Overall
Total	54	13		67
Oestrogen receptor status
≤ 10 fmol/mg	25	10	0.05*	35
> 10 fmol/mg	29	3		32
Node status
Negative	36	8	0.73	44
Positive	18	5		23
Histologic grade
Grade I	4	0	0.48	4
Grade II	17	5		22
Grade III	22	7		29
'Other'	11	1		12
Nottingham Prognostic Index
GPG score ≤ 3.4	4	1	0.61	6
MPG score 3.4–5.4	28	8		40
PPG score > 5.4	7	3		10
Age
< 50 years	19	8		28
≥ 50 years	35	5		39
Median (range)	56 (32–80)	46 (37–67)	0.03*	55 (32–80)
Tumour size
≤ 2 cm	15	4		19
> 2 cm	39	9		48
Median (range)	2.5 (1–5.5)	2.6 (1–5.3)	0.76	2.5 (1–5.5)

GPG, good prognostic group; MPG, moderate prognostic group; PPG, poor prognostic group. *Relationship reached significance (P ≤ 0.05).

ISSN: 1465-542X