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Table 3 Cancer incidence in first-degree relatives ofBRCA1/BRCA2 carriers

From: Cancer incidence in relatives of a population-based set of cases of early-onset breast cancer with a known BRCA1 and BRCA2mutation status

ICD-7 Site Observed (n) Expected (n) Standardized incidence ratio 95% confidence interval
140–209 All malignant tumours 20 7.3 2.7 1.7–4.2
Non-170 All malignant tumours except breast 12 6.2 1.9 1.0–1.6
151 Stomach 0 0.21 0 0–17.3
153 Large bowel 0 0.44 0 0–8.3
157 Pancreas 1 0.17 5.8 0.15–32.2
170 Breast 8 1.1 7.2 3.1–14.3
171 Cervix uteri 0 0.17 0 0–21.5
175 Ovaries 3 0.20 14.9 3.1–43.7
176 Vulva, vagina 1 0.02 45.6 1.1–254
177 Prostate 2 0.82 2.4 0.30–8.8
190 Melanoma 1 0.36 2.8 0.70–15.6
191 Skin, nonmelanoma 0 0.19 0 0–19.8
193 Central nervous system 1 0.40 2.5 0.06–13.9
194 Thyroid 1 0.17 5.9 0.15–33.0
  1. Age 0–79 years; n = 82; 3106.4 person-years; 1958–2000.