Table 3 Cancer incidence in first-degree relatives ofBRCA1/BRCA2 carriers
ICD-7 | Site | Observed (n) | Expected (n) | Standardized incidence ratio | 95% confidence interval |
|---|---|---|---|---|---|
140–209 | All malignant tumours | 20 | 7.3 | 2.7 | 1.7–4.2 |
Non-170 | All malignant tumours except breast | 12 | 6.2 | 1.9 | 1.0–1.6 |
151 | Stomach | 0 | 0.21 | 0 | 0–17.3 |
153 | Large bowel | 0 | 0.44 | 0 | 0–8.3 |
157 | Pancreas | 1 | 0.17 | 5.8 | 0.15–32.2 |
170 | Breast | 8 | 1.1 | 7.2 | 3.1–14.3 |
171 | Cervix uteri | 0 | 0.17 | 0 | 0–21.5 |
175 | Ovaries | 3 | 0.20 | 14.9 | 3.1–43.7 |
176 | Vulva, vagina | 1 | 0.02 | 45.6 | 1.1–254 |
177 | Prostate | 2 | 0.82 | 2.4 | 0.30–8.8 |
190 | Melanoma | 1 | 0.36 | 2.8 | 0.70–15.6 |
191 | Skin, nonmelanoma | 0 | 0.19 | 0 | 0–19.8 |
193 | Central nervous system | 1 | 0.40 | 2.5 | 0.06–13.9 |
194 | Thyroid | 1 | 0.17 | 5.9 | 0.15–33.0 |