Cancer incidence in relatives of a population-based set of cases of early-onset breast cancer with a known BRCA1 and BRCA2mutation status

Table 1 Cancer incidences in first-degree relatives of BRCA1/BRCA2 noncarriers

ICD-7	Site	Observed (n)	Expected (n)	Standardized incidence ratio	95% confidence interval
140–209	All malignant tumours	120	82.3	1.5	1.2–1.7
Non-170	All malignant tumours except breast	91	69.9	1.3	1.1–1.6
140	Lip	1	0.50	2.0	0.05–11.1
141 + 143–144	Cavum oris	0	0.56	0	0–6.6
142	Salivary glands	1	0.31	3.2	0.08–17.8
145–148	Throat	0	0.40	0	0–9.1
150	Oesophagus	0	0.53	0	0–6.9
151	Stomach	2	2.8	0.71	0.09–2.6
153	Large bowel	5	5.6	0.89	0.29–2.1
154	Rectum	6	3.8	1.6	0.58–3.5
1550	Liver	1	0.61	1.6	0.04–9.1
1551–1559	Gall tract	1	1.2	0.85	0.02–4.8
157	Pancreas	0	2.3	0	0–1.6
160	Nose and sinuses	0	0.18	0	0–20.4
161	Larynx	0	0.50	0	0–7.3
1620–1621	Trachea and lung	8	6.6	1.2	0.53–2.4
1622	Pleura	0	0.21	0	0–17.8
170	Breast	29	12.4	2.3	1.6–3.4
171	Cervix uteri	5	1.5	3.3	1.1–7.6
172 + 174	Uterine corpus	2	3.0	0.68	0.80–2.4
175	Ovaries	3	2.5	1.2	0.24–3.5
176	Vulva, vagina	0	0.32	0.0	0–11.7
177	Prostate	17	9.9	1.7	1.0–2.8
178	Testes	0	0.61	0	0–6.0
180	Kidneys	3	3.2	0.93	0.19–2.7
181	Bladder and urinary tract	3	3.9	0.76	0.16–2.2
190	Melanoma	5	3.2	1.5	0.4–93.5
191	Skin, nonmelanoma	6	2.1	2.8	1.0–6.1
193	Central nervous system	6	3.7	1.6	0.60–3.6
194	Thyroid	0	1.53	0	0–2.4
196–197	Bone, connective tissue	0	0.79	0	0–4.7
200 + 202	Non-Hodgkin's lymphoma	4	3.0	1.4	0.37–3.4
201	Hodgkin's disease	2	0.59	3.4	0.41–12.2
203	Myeloma	0	1.2	0	0–2.9
	Acute leukaemia	3	0.76	4.0	0.82–11.6
2041	Chronic lymphocytic leukaemia	1	0.84	1.2	0.03–6.6
2051	Chronic myelogenous leukaemia	0	0.25	0	0–14.9
208	Polycytaemia vera	0	0.34	0	0–10.8

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