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Table 1 Cancer incidences in first-degree relatives of BRCA1/BRCA2 noncarriers

From: Cancer incidence in relatives of a population-based set of cases of early-onset breast cancer with a known BRCA1 and BRCA2mutation status

ICD-7 Site Observed (n) Expected (n) Standardized incidence ratio 95% confidence interval
140–209 All malignant tumours 120 82.3 1.5 1.2–1.7
Non-170 All malignant tumours except breast 91 69.9 1.3 1.1–1.6
140 Lip 1 0.50 2.0 0.05–11.1
141 + 143–144 Cavum oris 0 0.56 0 0–6.6
142 Salivary glands 1 0.31 3.2 0.08–17.8
145–148 Throat 0 0.40 0 0–9.1
150 Oesophagus 0 0.53 0 0–6.9
151 Stomach 2 2.8 0.71 0.09–2.6
153 Large bowel 5 5.6 0.89 0.29–2.1
154 Rectum 6 3.8 1.6 0.58–3.5
1550 Liver 1 0.61 1.6 0.04–9.1
1551–1559 Gall tract 1 1.2 0.85 0.02–4.8
157 Pancreas 0 2.3 0 0–1.6
160 Nose and sinuses 0 0.18 0 0–20.4
161 Larynx 0 0.50 0 0–7.3
1620–1621 Trachea and lung 8 6.6 1.2 0.53–2.4
1622 Pleura 0 0.21 0 0–17.8
170 Breast 29 12.4 2.3 1.6–3.4
171 Cervix uteri 5 1.5 3.3 1.1–7.6
172 + 174 Uterine corpus 2 3.0 0.68 0.80–2.4
175 Ovaries 3 2.5 1.2 0.24–3.5
176 Vulva, vagina 0 0.32 0.0 0–11.7
177 Prostate 17 9.9 1.7 1.0–2.8
178 Testes 0 0.61 0 0–6.0
180 Kidneys 3 3.2 0.93 0.19–2.7
181 Bladder and urinary tract 3 3.9 0.76 0.16–2.2
190 Melanoma 5 3.2 1.5 0.4–93.5
191 Skin, nonmelanoma 6 2.1 2.8 1.0–6.1
193 Central nervous system 6 3.7 1.6 0.60–3.6
194 Thyroid 0 1.53 0 0–2.4
196–197 Bone, connective tissue 0 0.79 0 0–4.7
200 + 202 Non-Hodgkin's lymphoma 4 3.0 1.4 0.37–3.4
201 Hodgkin's disease 2 0.59 3.4 0.41–12.2
203 Myeloma 0 1.2 0 0–2.9
  Acute leukaemia 3 0.76 4.0 0.82–11.6
2041 Chronic lymphocytic leukaemia 1 0.84 1.2 0.03–6.6
2051 Chronic myelogenous leukaemia 0 0.25 0 0–14.9
208 Polycytaemia vera 0 0.34 0 0–10.8
  1. Age 0–79 years; n = 646; 25,244.0 person-years; 1958–2000.