Figure 2

Cumulative breast cancer incidences up to the age of 70 years of the different study cohorts. (a) Cumulative incidence of breast cancer (solid line) (dotted lines, 95% confidence interval) for first-degree relatives of breast cancer susceptibility gene 1 (BRCA1) and breast cancer susceptibility gene 2 (BRCA2) mutation noncarriers younger than age 41 years. A general female South Swedish population is added for comparison (dashed line). (b) Cumulative incidence of breast cancer (solid line) (dotted lines, 95% confidence interval) for women with at least two first-degree relatives with breast cancer, of which one is an index individual diagnosed younger than age 41 years and is without an identified BRCA1/BRCA2 germline mutation. A general female South Swedish population is added for comparison (dashed line). (c) Cumulative incidence of breast cancer (solid line) (dotted lines, 95% confidence interval) for first-degree relatives of BRCA1 and BRCA2 mutation carriers younger than age 41 years. A general female South Swedish population is added for comparison (dashed line). (d) Calculated cumulative incidence of breast cancer (solid line) (dotted lines, 95% confidence interval) for BRCA1 and BRCA2 mutation carriers younger than age 41 years. A general female South Swedish population is added for comparison (dashed line).