Table 1 Targeted therapies in clinical development
From: The future of cytotoxic therapy: selective cytotoxicity based on biology is the key
Target | Agent | Agent class |
|---|---|---|
EGFR | IMC-C225 Cetuximab, Erbitux (Imclone) | Monoclonal antibody |
| Â | ABX-EGF (Abgenix) | Monoclonal antibody |
| Â | EMD 72000 (Merck KgaA Darmstadt) | Monoclonal antibody |
| Â | ZD 1839 gefitinib, Iressa (AstraZeneca) | Small molecule kinase inhibitor |
| Â | OSI-774, erlotinib, Tarceva(OSI-Pharmaceuticals) | Small molecule kinase inhibitor |
| Â | CI-1033/PD183805 (Pfizer) | Small molecule kinase inhibitor |
| Â | EKB-569 (Wyeth Ayerst) | Small molecule kinase inhibitor |
| Â | GW2016/572016(GlaxoSmithKline) | Small molecule kinase inhibitor |
HER2/neu | Trastuzumab, Herceptin(Genentech) | Monoclonal antibody |
| Â | 2C4 (Genentech) | Monoclonal antibody |
| Â | 17-AAG | Geldanamycin derivative inhibits HSP90 |
| Â | TAK-165(Takeda Pharmaceuticals) | Small molecule inhibitor |
| Â | GW2016/572016(GlaxoSmithKline) | Small molecule kinase inhibitor |
| Â | CP 724, 714 (Pfizer) | Small molecule inhibitor |
Ras | R115777(Johnson and Johnson) | Farnesyl transferase inhibitor |
| Â | SCH66336 (Schering-Plough) | Farnesyl transferase inhibitor |
| Â | BMS214662(Bristol Myers Squibb) | Farnesyl transferase inhibitor |
| Â | CT-2584HMS (Cell Therapeutics) | Farnesyl transferase inhibitor |
Raf | BAY 43-9006 (Onyx/Bayer) | Small molecule kinase inhibitor |
MEK | PD 184352/CI-1040 (Pfizer) | Small molecule kinase inhibitor |
PKC-α | ISIS 3521/LY900003 Affinitak(ISIS Pharmaceuticals) | Antisense oligonucleotide |
| Â | CGP41251/PKC412 (Novartis) | Staurosporine analogue |
| Â | Bryostatin-1 | Small molecule kinase inhibitor |
| Â | UCN-01 (Kyowa Hakko Kogyo) | Staurosporine analogue |
PKC-β | LY333531 (Eli Lilly) | Small molecule kinase inhibitor |
Akt | 17-AAG | Inhibitor of HSP90 |
| Â | Perifosine (Zenataris) | Alkylphospholipid |
mTOR | CCI-779 (Wyeth) | Inhibits mTOR kinase by binding to FKBP |
| Â | RAD001 (Novartis) | Inhibits mTOR kinase by binding to FKBP |