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Table 1 Distribution of breast cancer risk factors among controls in relation to the CYP17 genotype: Western New York Breast Cancer Study

From: CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors

  Premenopausal (n = 86) Postmenopausal (n = 102)
CYP17 genotype A1/A1 A1/A2 and A2/A2 A1/A1 A1/A2 and A2/A2
Age at menarche
   < 13 years 15 (31) 18 (49) 18 (38) 25 (46)
   ≥ 13 years 33 (69) 20 (51) 29 (62) 30 (54)
Difficulty getting pregnant
   No 38 (79) 29 (76) 32 (68)* 47 (86)*
   Yes 10 (21) 9 (24) 11 (23) 8 (14)
Age at first birth
   < 25 years 38 (79) 28 (74) 21 (45)* 40 (73)*
   ≥ 25 years 10 (21) 10 (26) 26 (55) 15 (27)
Ever use oral contraceptives
   No 26 (54) 19 (50)   
   Yes 22 (46) 19 (50)   
Family history of breast cancer
   No 45 (94) 35 (92) 43 (91) 50 (91)
   Yes 3 (6) 3 (8) 4 (9) 5 (9)
Age at menopause
   < 48 years    29 (62) 29 (53)
   ≥ 48 years    18 (38) 26 (47)
Ever use hormone replacement therapy
   No    32 (68) 39 (71)
   Yes    15 (32) 16 (29)
  1. Data presented as n (%). * Statistically significant (P < 0.05).