Figure 1
From: Tyrosine kinase signalling in breast cancer: Fibroblast growth factors and their receptors
Fgf receptor structure and Fgf signalling. Structural domains of an Fgf receptor are shown on the right of the panel. Fgf signal transduction is initiated upon binding the Fgf ligand in conjunction with heparan sulphate to form a ternary complex. The result is autophosphorylation and activation of the tyrosine kinase, which facilitates second messenger signalling through phosphotyrosine-dependent and -independent interactions with the cytoplasmic portion of the receptor.