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Table 2 Least-squares mean percentage breast density by genotype

From: Genetic determinants of mammographic density

Genotype All women* mean (n) Caucasians** mean (n) African-Americans** mean (n)
CYP17    
   A1/A1 34.1 (144) 33.7 (87) 34.6 (57)
   A1/A2 34.8 (204) 34.6 (127) 35.0 (77)
   A2/A2 37.2 (48) 39.1 (30) 34.6 (18)
P trend 0.40 0.26 0.95
COMT    
   Val/Val 33.4 (139) 34.3 (76) 32.3 (63)
   Val/Met 35.8 (175) 35.6 (104) 36.2 (71)
   Met/Met 34.9 (82) 34.2 (64) 37.7 (18)
P trend 0.46 0.99 0.19
17HSDB1    
   Gly/Gly 32.4 (109) 32.0 (71) 33.3 (38)
   Gly/Ser 35.8 (191) 35.9 (121) 35.6 (70)
   Ser/Ser 35.6 (96) 36.1 (52) 34.9 (44)
P trend 0.24 0.22 0.73
3HSDB1    
   Asn/Asn 35.4 (240) 37.4 (131) 32.9 (109)
   Asn/Thr 33.6 (126) 31.5 (88) 38.4 (38)
   Thr/Thr 35.1 (27) 32.3 (23) 52.6 (4)
P trend 0.58 0.04 0.02
  1. *Adjusted for race, age, body mass index (BMI), menopausal status/ hormone replacement therapy (HRT) use, parity, age at first birth, age at menarche and first-degree family of breast cancer. **Adjusted for age, BMI, menopausal status/HRT use, parity, age at first birth, age at menarche and first-degree family of breast cancer.