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Table 2 Least-squares mean percentage breast density by genotype

From: Genetic determinants of mammographic density

Genotype

All women* mean (n)

Caucasians** mean (n)

African-Americans** mean (n)

CYP17

   

   A1/A1

34.1 (144)

33.7 (87)

34.6 (57)

   A1/A2

34.8 (204)

34.6 (127)

35.0 (77)

   A2/A2

37.2 (48)

39.1 (30)

34.6 (18)

P trend

0.40

0.26

0.95

COMT

   

   Val/Val

33.4 (139)

34.3 (76)

32.3 (63)

   Val/Met

35.8 (175)

35.6 (104)

36.2 (71)

   Met/Met

34.9 (82)

34.2 (64)

37.7 (18)

P trend

0.46

0.99

0.19

17HSDB1

   

   Gly/Gly

32.4 (109)

32.0 (71)

33.3 (38)

   Gly/Ser

35.8 (191)

35.9 (121)

35.6 (70)

   Ser/Ser

35.6 (96)

36.1 (52)

34.9 (44)

P trend

0.24

0.22

0.73

3HSDB1

   

   Asn/Asn

35.4 (240)

37.4 (131)

32.9 (109)

   Asn/Thr

33.6 (126)

31.5 (88)

38.4 (38)

   Thr/Thr

35.1 (27)

32.3 (23)

52.6 (4)

P trend

0.58

0.04

0.02

  1. *Adjusted for race, age, body mass index (BMI), menopausal status/ hormone replacement therapy (HRT) use, parity, age at first birth, age at menarche and first-degree family of breast cancer. **Adjusted for age, BMI, menopausal status/HRT use, parity, age at first birth, age at menarche and first-degree family of breast cancer.