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PB.38. Extent of agreement between radiological and pathological size and factors affecting completeness of excision in breast-conserving surgery for invasive breast cancer

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Breast Cancer Research201416(Suppl 1):P55

https://doi.org/10.1186/bcr3744

Published: 3 November 2014

Keywords

  • Breast Cancer
  • Cancer Research
  • Retrospective Study
  • Tumour Size
  • Local Recurrence

Introduction

Completeness of excision is the most important factor influencing local recurrence for invasive breast cancer. The aim of this study was to determine whether or not radiological underestimation of tumour size increased the risk of incomplete excision in patients undergoing breast-conserving surgery (BCS).

Methods

This was a retrospective study of 311 women diagnosed with invasive breast cancer and treated with BCS. Data were extracted from patient notes.

Results

Mean underestimation of tumour size was 11.69 mm for mammography and 17.18 mm for ultrasonography in the incomplete excision group. For every 1 mm increase in mammographical and ultrasonographical underestimation, the risk of incomplete excision rose by 10% and 14% respectively. T stage, maximum tumour diameter, multifocal disease, an in situ component and mammographical underestimation all significantly increased the risk of incomplete excision when applied to a best-fit model. The larger the size of the in situ component, the greater the risk of both radiological underestimation and incomplete excision.

Conclusion

Underestimation of tumour size by current radiological techniques increases the risk of incomplete excision in women undergoing BCS. Better preoperative assessment of tumour size is required to reduce this risk. Larger, prospective studies are needed to verify the associations found here.

Authors’ Affiliations

(1)
University of Edinburgh/Edinburgh Breast Unit, Edinburgh, UK

Copyright

© Newlands et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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