At baseline, mean tumour ADC (0.92 × 10-3 mm2/second) was statistically lower than disease-free fibroglandular breast tissue (1.75 × 10-3 mm2/second) (P < 0.0001). Mean FA values of tumour (FA = 0.139) and disease-free tissue (FA = 0.135) were similar. Compared with baseline values, tumour ADC of responders significantly increased at TP1 (P < 0.0001) and TP2 (P < 0.0001) while a significant increase in tumour FA of responders was seen at TP2 (P < 0.008). No statistical change occurred in tumour ADC or FA values of the nonresponder group. The ADC value of the clip in the phantom (1.7 × 10-3 mm2/second) was higher than the ADC value of surrounding tumour (1.4 × 10-3 mm2/second).