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PB.26. MRI-guided breast biopsy in Leeds: 12 years' experience


MRI-guided biopsy allows sampling of lesions occult on conventional imaging to reach a preoperative histological diagnosis and guide patient management.


We performed a retrospective audit of all MRI-guided biopsies performed in Leeds patients over a 12-year study period from the initiation of this service in April 2002. Data collected: indication for MRI; pre-biopsy MRI score; histology from MRI-guided biopsy and final surgery.


There were 46 MR-guided breast biopsies performed (symptomatic n = 26, screening n = 20). Indication for MRI was to assess extent of malignancy (n = 29), an adjunct to triple assessment (n = 11) and a screening investigation in higher risk patients (n = 6). Pre-biopsy MRI score was classified as indeterminate MRI 3 (n = 22), suspicious MRI 4 (n = 20) and malignant MRI 5 (n = 4). In the MRI 3 subgroup, five proved malignant at MR-guided biopsy with a positive predictive value of 23% (5/22). In the MRI 4/5 subgroup, 14 proved malignant at MR-guided biopsy and a further four malignant lesions were identified at diagnostic surgical biopsy, with an overall positive predictive value of 75% (18/24).


MRI-detected lesions are interpreted in clinical context and attributed an MRI score. If the patient has an increased risk of cancer or there already is a cancer present, any additional lesion should be regarded with a higher level of suspicion. MRI 4/5 lesions have a high positive predictive value for malignancy and should proceed to diagnostic surgical biopsy if the initial MR-guided biopsy is inconclusive.

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Rajan, S., Sharma, N. & Dall, B. PB.26. MRI-guided breast biopsy in Leeds: 12 years' experience. Breast Cancer Res 16 (Suppl 1), P10 (2014).

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