Poster presentation | Open | Published:
PB.26. MRI-guided breast biopsy in Leeds: 12 years' experience
Breast Cancer Researchvolume 16, Article number: P10 (2014)
MRI-guided biopsy allows sampling of lesions occult on conventional imaging to reach a preoperative histological diagnosis and guide patient management.
We performed a retrospective audit of all MRI-guided biopsies performed in Leeds patients over a 12-year study period from the initiation of this service in April 2002. Data collected: indication for MRI; pre-biopsy MRI score; histology from MRI-guided biopsy and final surgery.
There were 46 MR-guided breast biopsies performed (symptomatic n = 26, screening n = 20). Indication for MRI was to assess extent of malignancy (n = 29), an adjunct to triple assessment (n = 11) and a screening investigation in higher risk patients (n = 6). Pre-biopsy MRI score was classified as indeterminate MRI 3 (n = 22), suspicious MRI 4 (n = 20) and malignant MRI 5 (n = 4). In the MRI 3 subgroup, five proved malignant at MR-guided biopsy with a positive predictive value of 23% (5/22). In the MRI 4/5 subgroup, 14 proved malignant at MR-guided biopsy and a further four malignant lesions were identified at diagnostic surgical biopsy, with an overall positive predictive value of 75% (18/24).
MRI-detected lesions are interpreted in clinical context and attributed an MRI score. If the patient has an increased risk of cancer or there already is a cancer present, any additional lesion should be regarded with a higher level of suspicion. MRI 4/5 lesions have a high positive predictive value for malignancy and should proceed to diagnostic surgical biopsy if the initial MR-guided biopsy is inconclusive.