Table 1 Relationship between PIK3CA mutation status and standard clinicopathological parameters a
Number of patients (% in brackets) | ||||
|---|---|---|---|---|
Demographic characteristics | Total population number (%) | PIK3CA WT, n(%) | PIK3CA mutation, n(%) | P-valueb |
Totals | 85 (100) | 60 (70.6) | 25 (29.4) | |
Mean age (±SD), yr | 70.9 (8.5) | 71.0 (8.4) | 70.7 (9.0) | |
Histological grade | 0.033 | |||
Number available | 70 | 47 | 23 | |
1 | 13 (18.6) | 5 (10.6) | 8 (34.8) | |
2 | 43 (61.4) | 30 (63.8) | 13 (56.5) | |
3 | 14 (20.0) | 12 (25.5) | 2 (8.7) | |
Unknown | 15 | |||
Stage (n = 85) | 0.780 | |||
2 | 48 (56.5) | 33 (55.0) | 15 (60.0) | |
3 | 28 (32.9) | 21 (35.0) | 7 (28.0) | |
4 | 9 (10.6) | 6 (10.0) | 3 (12.0) | |
Lymph nodes (n = 85) | 0.472 | |||
Positive | 35 (41.2) | 23 (38.3) | 12 (48.0) | |
Negative | 50 (58.8) | 37 (61.7) | 13 (52.0) | |
Tumour sizec (n = 76) | 0.610 | |||
T2 | 48 (63.2) | 33 (61.1) | 15 (68.2) | |
T3 | 28 (36.8) | 21 (38.9) | 7 (31.2) | |
Histology | 0.725 | |||
Number available | 58 | 38 | 20 | |
Ductal | 44 (75.9) | 29 (76.3) | 15 (75) | |
Lobular | 8 (13.8) | 6 (15.8) | 2 (10) | |
Other | 6 (10.3) | 3 (7.9) | 3 (15) | |
Unknown | 27 | |||
ERα status | 1.000 | |||
Number available | 83 | 25 | 58 | |
Negative | 0 | 0 | 0 | |
Positive | 83 (100) | 25 (100) | 58 (100) | |
Unknown | 2 | |||
PgR status | 0.49 | |||
Number available | 83 | 58 | 25 | |
Negative | 11 (12.9) | 9 (15.5) | 2 (8) | |
Positive | 72 (86.7) | 49 (84.5) | 23 (92) | |
Unknown | 2 | |||
HER2 status | 1.000 | |||
Number available | 82 | 57 | 25 | |
Negative | 69 (84.1) | 48 (84.2) | 21 (84) | |
Positive | 13 (15.9) | 9 (15.8) | 4 (16) | |
Unknown | 3 | |||
Subtype | 0.039 | |||
Number available | 46 | 23 | 13 | |
Luminal A | 22 (47.8) | 11 (47.8) | 11 (84.6) | |
Luminal B | 24 (52.2) | 12 (52.2) | 2 (15.4) | |