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Table 2 Multivariate analysis of clinicopathological parameters

From: Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity

  Overall survival Disease-free survival
Variables HR (95% Cl) P* HR (95% Cl) P*
H4K20me3 score (score2 : score 0,1) 2.85 (0.52 to 53.37) 0.263 3.37 (1.09 to 14.80) 0.033
Nuclear grade (G1, G2 : G3) 5.60 (1.19 to 41.07) 0.028 2.52 (0.97 to 6.75) 0.059
ER (positive : negative) 0.93 (0.18 to 3.70) 0.920 1.70 (0.65 to 4.38) 0.272
HER2 (positive : negative) 2.62 (0.67 to 9.30) 0.158 1.43 (0.46 to 3.70) 0.509
  1. *Cox proportional hazards model was used to assess the independent prognostic contribution of H4K20me3 after accounting for other potentially important covariates. HR, hazard ratio; Cl, confidence interval.