Table 4 Reclassification of five-year absolute risk of breast cancer based on a risk model containing Gail variables with and without genetic risk scores (GRS) on 411 breast cancer patients and 1,212 healthy women, The Singapore Chinese Health Study, 1993 to 1998
Five-year risk without GRS (%) | Five-year risk with GRS (%) | |||||
|---|---|---|---|---|---|---|
<1.0 | 1.0 - <1.5 | 1.5 - <2.0 | 2.0 - <2.5 | ≥2.5 | Total | |
<1.0 | Â | Â | Â | Â | Â | Â |
Control | 511 | 84 | 0 | 0 | 0 | 595 |
Case | 109 | 46 | 0 | 0 | 0 | 155 |
1.0 - <1.5 | Â | Â | Â | Â | Â | Â |
Control | 90 | 356 | 33 | 0 | 0 | 479 |
Case | 36 | 123 | 39 | 0 | 0 | 198 |
1.5 - <2.0 | Â | Â | Â | Â | Â | Â |
Control | 0 | 53 | 50 | 12 | 0 | 115 |
Case | 0 | 13 | 19 | 12 | 0 | 44 |
2.0 - <2.5 | Â | Â | Â | Â | Â | Â |
Control | 0 | 0 | 12 | 3 | 1 | 16 |
Case | 0 | 0 | 4 | 2 | 3 | 9 |
>2.5 | Â | Â | Â | Â | Â | Â |
Control | 0 | 0 | 0 | 2 | 5 | 7 |
Case | 0 | 0 | 0 | 1 | 4 | 5 |
Total | Â | Â | Â | Â | Â | Â |
Control | 601 | 493 | 94 | 18 | 6 | 1,212 |
Case | 145 | 182 | 62 | 15 | 7 | 411 |