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Figure 2 | Breast Cancer Research

Figure 2

From: Breast-related effects of selective estrogen receptor modulators and tissue-selective estrogen complexes

Figure 2

Molecular activity of selective estrogen receptor modulators (SERMs) at estrogen receptors. When a SERM binds to the estrogen receptor, the receptor adopts a unique conformation that allows dimerization and interaction with estrogen response elements (EREs) of the target genes. The unique conformational change induced by binding of the SERM may result in a distinct pattern of cofactor recruitment. Reprinted with permission from Elsevier [43].

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Breast Cancer Research

ISSN: 1465-542X

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