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Table 2 Diagnostic performance of five-protein and four-protein classification models

From: Novel serum protein biomarker panel revealed by mass spectrometry and its prognostic value in breast cancer

Model Cancer patients Healthy volunteers Sensitivity (%) Specificity (%) Overall accuracy (%) ROC-AUC
Five-protein panel
Training set 92* 46* 97.6 87.1 93.1 0.961
Validation set 95* 68* 86.8 92.4 89.4 0.939
Four-protein panel
Training set 92* 46* 90.5 79.9 85.3 0.935
Validation set 95* 68* 92.6 82.4 88.6 0.954
  1. *included mass spectrometry (MS) spectra after normalization. ROC-AUC, receiver operating characteristic-area under the curve.