Upstream regulator | Predicted activation state | Activation z-score | P-value of overlap |
---|---|---|---|
BNIP3L | Activated | 3.05 | 5.60E-12 |
TP53 | Activated | 2.82 | 8.44E-12 |
let-7 | Activated | 2.01 | 1.12E-10 |
KDM5B | Activated | 2.90 | 7.65E-07 |
CDKN2A | Activated | 2.70 | 1.91E-06 |
MAPK14 | Activated | 2.28 | 5.65E-06 |
TCF3 | Activated | 3.32 | 1.49E-05 |
CEBPD | Activated | 2.20 | 1.25E-04 |
PTHLH | Activated | 2.20 | 1.47E-04 |
UXT | Activated | 2.22 | 1.53E-04 |
TAZ | Activated | 2.00 | 6.60E-04 |
MAP3K7 | Activated | 2.30 | 7.45E-04 |
SMARCB1 | Activated | 2.14 | 1.47E-03 |
P38 MAPK | Activated | 2.29 | 6.01E-03 |
JUN | Activated | 2.03 | 1.85E-02 |
Vegf | Inhibited | −2.35 | 1.70E-09 |
CCND1 | Inhibited | −2.24 | 1.12E-08 |
MYC | Inhibited | −4.12 | 1.20E-08 |
E2F1 | Inhibited | −2.89 | 2.51E-07 |
TBX2 | Inhibited | −2.53 | 8.13E-07 |
FOXO1 | Inhibited | −3.56 | 1.67E-05 |
MYBL2 | Inhibited | −2.00 | 3.49E-03 |
MYCN | Inhibited | −2.38 | 7.17E-03 |
BMP7 | Inhibited | −2.39 | 1.19E-02 |
CDKN1A | Â | 1.60 | 4.35E-21 |
HGF |  | −1.77 | 1.39E-10 |
CDK4 | Â | Â | 1.82E-09 |
TGFβ1 |  | 0.68 | 9.63E-08 |
RB1 | Â | 1.14 | 8.23E-07 |
Tgf β |  | 0.88 | 9.33E-06 |