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Table 1 IPA upstream factor analysis of genes specifically expressed in PHBECs grown in co-cultures with hAMSCs

From: Mesenchymal precursor cells maintain the differentiation and proliferation potentials of breast epithelial cells

Upstream regulator Predicted activation state Activation z-score P-value of overlap
BNIP3L Activated 3.05 5.60E-12
TP53 Activated 2.82 8.44E-12
let-7 Activated 2.01 1.12E-10
KDM5B Activated 2.90 7.65E-07
CDKN2A Activated 2.70 1.91E-06
MAPK14 Activated 2.28 5.65E-06
TCF3 Activated 3.32 1.49E-05
CEBPD Activated 2.20 1.25E-04
PTHLH Activated 2.20 1.47E-04
UXT Activated 2.22 1.53E-04
TAZ Activated 2.00 6.60E-04
MAP3K7 Activated 2.30 7.45E-04
SMARCB1 Activated 2.14 1.47E-03
P38 MAPK Activated 2.29 6.01E-03
JUN Activated 2.03 1.85E-02
Vegf Inhibited −2.35 1.70E-09
CCND1 Inhibited −2.24 1.12E-08
MYC Inhibited −4.12 1.20E-08
E2F1 Inhibited −2.89 2.51E-07
TBX2 Inhibited −2.53 8.13E-07
FOXO1 Inhibited −3.56 1.67E-05
MYBL2 Inhibited −2.00 3.49E-03
MYCN Inhibited −2.38 7.17E-03
BMP7 Inhibited −2.39 1.19E-02
CDKN1A   1.60 4.35E-21
HGF   −1.77 1.39E-10
CDK4    1.82E-09
TGFβ1   0.68 9.63E-08
RB1   1.14 8.23E-07
Tgf β   0.88 9.33E-06
  1. PHBECs, primary human breast epithelial cells; hAMSCs: human adipose tissue-derived mesenchymal stem cells; IPA: Ingenuity pathway analysis.