|
Upstream regulator
|
Predicted activation state
|
Activation z-score
|
P-value of overlap
|
|---|
|
BNIP3L
|
Activated
|
3.05
|
5.60E-12
|
|
TP53
|
Activated
|
2.82
|
8.44E-12
|
|
let-7
|
Activated
|
2.01
|
1.12E-10
|
|
KDM5B
|
Activated
|
2.90
|
7.65E-07
|
|
CDKN2A
|
Activated
|
2.70
|
1.91E-06
|
|
MAPK14
|
Activated
|
2.28
|
5.65E-06
|
|
TCF3
|
Activated
|
3.32
|
1.49E-05
|
|
CEBPD
|
Activated
|
2.20
|
1.25E-04
|
|
PTHLH
|
Activated
|
2.20
|
1.47E-04
|
|
UXT
|
Activated
|
2.22
|
1.53E-04
|
|
TAZ
|
Activated
|
2.00
|
6.60E-04
|
|
MAP3K7
|
Activated
|
2.30
|
7.45E-04
|
|
SMARCB1
|
Activated
|
2.14
|
1.47E-03
|
|
P38 MAPK
|
Activated
|
2.29
|
6.01E-03
|
|
JUN
|
Activated
|
2.03
|
1.85E-02
|
|
Vegf
|
Inhibited
|
−2.35
|
1.70E-09
|
|
CCND1
|
Inhibited
|
−2.24
|
1.12E-08
|
|
MYC
|
Inhibited
|
−4.12
|
1.20E-08
|
|
E2F1
|
Inhibited
|
−2.89
|
2.51E-07
|
|
TBX2
|
Inhibited
|
−2.53
|
8.13E-07
|
|
FOXO1
|
Inhibited
|
−3.56
|
1.67E-05
|
|
MYBL2
|
Inhibited
|
−2.00
|
3.49E-03
|
|
MYCN
|
Inhibited
|
−2.38
|
7.17E-03
|
|
BMP7
|
Inhibited
|
−2.39
|
1.19E-02
|
|
CDKN1A
| |
1.60
|
4.35E-21
|
|
HGF
| |
−1.77
|
1.39E-10
|
|
CDK4
| | |
1.82E-09
|
|
TGFβ1
| |
0.68
|
9.63E-08
|
|
RB1
| |
1.14
|
8.23E-07
|
|
Tgf β
| |
0.88
|
9.33E-06
|
- PHBECs, primary human breast epithelial cells; hAMSCs: human adipose tissue-derived mesenchymal stem cells; IPA: Ingenuity pathway analysis.
