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Table 4 rs10235235 and risk of breast cancer for women of European ancestry by age at menarche

From: Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

Age at menarche (years) Cases Controls ORhet 95% CI P 1 ORhom 95% CI P 1 P het
≤11 4,818 4,749 1.06 0.95, 1.19 0.30 1.07 0.67, 1.72 0.78  
12 5,655 5,720 0.92 0.83, 1.02 0.10 0.83 0.54, 1.28 0.41  
13 7,308 7,379 0.93 0.85, 1.02 0.11 0.77 0.54, 1.09 0.14  
14 5,307 5,743 0.96 0.86, 1.06 0.42 0.69 0.45, 1.06 0.09  
≥15 4,385 4,667 0.84 0.75, 0.94 0.003 0.81 0.51, 1.30 0.39  
Total 27,473 28,258 0.94 0.90, 0.98 0.007 0.81 0.67, 0.98 0.03 0.02
  1. H0, null hypothesis; ORhet, odds ratio comparing rs10235235 AG genotype versus AA genotype; ORhom, odds ratio comparing rs10235235 GG genotype versus AA genotype; P1, test of H0 no association between rs10235235 and breast cancer risk; Phet, test of H0 no linear trend in stratum specific estimates.
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