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Table 2 rs10235235 and risk of breast cancer for women of European ancestry by age at diagnosis

From: Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

Age at diagnosis Casesa Controlsa ORhet 95% CI P 1 ORhom 95% CI P 1 P het
≤ 50 years 11,794 34,988 0.99 0.93, 1.05 0.69 0.68 0.53, 0.86 0.003  
> 50 years 23,264 34,988 0.97 0.93, 1.02 0.24 0.84 0.70, 1.00 0.04  
NK 554         
Total 35,612 34,988 0.98 0.94, 1.02 0.23 0.79 0.67, 0.92 0.003 0.89
  1. aFive studies (ABCFS, MARIE, MEC, MTLGEBCS and SASBAC) that selected all cases on the basis of age at diagnosis (Table S3 in Additional file 1) were excluded from this stratified analysis; two small studies (CTS and NBCS) that had no heterozygote or rare homozygote cases in one of the age stratum were also excluded. H0, null hypothesis; NK, not known; ORhet, odds ratio comparing rs10235235 AG genotype versus AA genotype; ORhom, odds ratio comparing rs10235235 GG genotype versus AA genotype; P1, test of H0 no association between rs10235235 and breast cancer risk; Phet, test of H0 no difference between stratum specific estimates.
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