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Table 2 Univariable and multivariable analysis of response rates according to various prognostic groups (N = 119)

From: Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer

Variable Univariable analysis Multivariable analysis
Response rates (%) P-value P-value Odds ratio (95% CI)
Age     
>50 15  
≤50 27 0.180
T stage     
T1 15  
T2 19  
T3 39 0.082
Nodal status     
Positive 18   
Negative 39 0.046 0.026 4.44 (1.23 to 16.41)
Histological type     
IDC 24  
ILD 0 0.119
Pathological grade     
1 or 2 2    
3 34 <0.0001 0.002 31.25 (3.51 to 250.01)
Breast cancer subtype     
Luminal A 8    
Luminal B 16    
HER2 23    
TN 41(TN vs. others) 0.008 0.033 3.41 (1.10 to 10.86)
Ki67 (N = 106)     
>20% 16  
≤20% 26 0.236
Treatment arm     
 A 22   
 B 21 1.0  
ALDH1     
 Positive 10    
 Negative 32 0.007 0.004 5.76 (1.76 to 18.45)
  1. ALDH1, aldehyde dehydrogenase-1; HER2, human epidermal growth factor receptor 2; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; TN, triple negative.