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Table 2 Univariable and multivariable analysis of response rates according to various prognostic groups (N = 119)

From: Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer

Variable

Univariable analysis

Multivariable analysis

Response rates (%)

P-value

P-value

Odds ratio (95% CI)

Age

    

 >50

15

 

 ≤50

27

0.180

T stage

    

 T1

15

 

 T2

19

 

 T3

39

0.082

Nodal status

    

 Positive

18

  

 Negative

39

0.046

0.026

4.44 (1.23 to 16.41)

Histological type

    

 IDC

24

 

 ILD

0

0.119

Pathological grade

    

 1 or 2

2

   

 3

34

<0.0001

0.002

31.25 (3.51 to 250.01)

Breast cancer subtype

    

 Luminal A

8

   

 Luminal B

16

   

 HER2

23

   

 TN

41(TN vs. others)

0.008

0.033

3.41 (1.10 to 10.86)

Ki67 (N = 106)

    

 >20%

16

 

 ≤20%

26

0.236

Treatment arm

    

 A

22

  

 B

21

1.0

 

ALDH1

    

 Positive

10

   

 Negative

32

0.007

0.004

5.76 (1.76 to 18.45)

  1. ALDH1, aldehyde dehydrogenase-1; HER2, human epidermal growth factor receptor 2; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; TN, triple negative.
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Breast Cancer Research

ISSN: 1465-542X

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