Table 2 Univariate Cox proportional hazards ratios and 95% confidence intervals in univariate analyses for association between EndoPredict, clinicopathological variables and metastasis-free survival

EP

1.207 (1.134 to 1.285)

<0.0001

EPclin

1.916 (1.625 to 2.259)

<0.0001

Age

0.977 (0.960 to 0.993)

0.0065

Tumor size

0.0159^b

  ≤1

Reference value

  >1 to ≤2 cm

1.038 (0.457 to 2.357)

0.9290

  >2 to ≤5 cm

1.919 (0.884 to 4.168)

0.0994

  >5 cm

2.102 (0.762 to 5.798)

0.1511

Number of positive nodes

<0.0001^b

  1 to 3

Reference value

  4 to 10

1.631 (1.085 to 2.451)

0.0187

  >10

4.911 (3.022 to 7.979)

<0.0001

Grade

0.0233^b

  G1

Reference value

  G2

2.263 (1.157 to 4.428)

0.0171

  G3

2.883 (1.446 to 5.746)

0.0026

  Unknown

1.844 (0.749 to 4.538)

0.1829

Treatment arm

0.6067^b

  FEC

Reference value

  FEC-P

0.910 (0.635 to 1.304)

ER (Allred score ^c )

0.950 (0.886 to 1.019)

0.1505

PR (Allred score ^c )

0.923 (0.874 to 0.974)

0.0033

Ki67 (quantitative)

1.017 (1.004 to 1.030)

0.0080