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Table 2 Summary statistics of the reference values produced by observers, visual estimates and image analyses (n = 30)

From: A methodology to ensure and improve accuracy of Ki67 labelling index estimation by automated digital image analysis in breast cancer tissue

Variable Median Mean Std dev Std error Min Max
Ki67-Count-1 21.7 28.6 20.4 3.7 0.3 72.6
Ki67-Count-2 24 29.9 19.5 3.6 0.6 69.7
Ki67-Count-3 23 28.7 18.6 3.4 1.2 69.4
Ki67-Count-median 24 29.3 19.4 3.5 0.6 67.4
Ki67-Count-mean 23.4 29.1 19.4 3.5 0.7 66.8
Total profiles Observer 1 331 425.7 273.7 50 85 1,098
Total profiles Observer 2 509 590.7 385.4 70.4 143 1,863
Total profiles Observer 3 471.5 547.2 331.9 60.6 146 1,544
Ki67-VE-1 10 18.3 15.3 2.8 5 70
Ki67-VE-2 30 40.2 29.4 5.4 2 95
Ki67-VE-3 37.5 41.4 27.7 5.1 1 90
Ki67-VE-4 20 30.2 23 4.2 4 80
Ki67-VE-5 22.5 31 24.1 4.4 1 90
Ki67-VE-median 22.5 32.5 25 4.6 2 90
Ki67-VE-mean 23.4 32.2 23.2 4.2 6.2 80
Ki67-DIA-0 16.1 19.9 12.5 2.3 2.1 50
Ki67-DIA-1 18.5 24.8 15.9 2.9 1.6 65.5
Ki67-DIA-2 22.8 29.1 15.7 2.9 9.1 68.4