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Table 1 Mean ± SE for continuous baseline covariates, and number (%) for categorical baseline covariates for breast cancer cases and controls occurring during the intervention phases of the Women’s Health Initiative CEE + MPA and CEE trials

From: Sex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects

 

CEE + MPA trial

CEE trial

 

Cases

Controls

P-value*

Cases

Controls

P-value*

N

348

348

 

235

235

 

Age

64.32 ± 6.85

64.33 ± 6.82

0.98

64.5 ± 7.11

64.49 ± 7.06

0.97

BMI

29.33 ± 5.56

28.46 ± 5.69

0.04

31.46 ± 5.98

29.32 ± 5.70

<0.01

Gail model five-year risk score (%)

1.85 ± 0.89

1.72 ± 0.84

0.05

1.84 ± 1.65

1.36 ± 0.90

0.08

Race (%)

  

0.99

  

0.98

White

305 (87.6)

305 (87.6)

 

184 (78.3)

184 (78.3)

Black

21 (6.0)

21 (6.0)

 

36 (15.3)

35 (14.9)

Other

22 (6.3)

22 (6.3)

 

15 (6.4)

16 (6.8)

Smoking (%)

  

0.11

  

0.72

Never

158 (46.1)

186 (54.1)

 

129 (55.1)

126 (53.6)

Past

155 (45.2)

131 (38.1)

 

87 (37.2)

86 (36.6)

Current

30 (8.7)

27 (7.8)

 

18 (7.7)

23 (9.8)

Family history of breast cancer (%)

  

0.006

  

0.23

Yes

79 (24.0)

50 (15.2)

52 (23.5)

42 (18.5)

No

250 (76.0)

280 (84.8)

 

169 (76.5)

185 (81.5)

 
  1. *P-values are significance levels from Student’s t-test and chi-square tests of no difference between cases and controls for continuous and categorical variables.
  2. Matching variables in control selection. BMI, body mass index; CEE, conjugated equine estrogens; MPA, medroxyprogesterone acetate.