Association of BD-L value with response to a combination of temozolomide and olaparib. Linear regression analyses of single and combination treatment with 40 nM olaparib and 100 uM temozolomide using: (A,B) BD-L metagene values calculated using datasets from (A) Neve et al.  and (B) Garnett et al. ; (C,D) BRCA1 breast cancer signature as described in van’t Veer et al.  calculated using data sets from (C) Neve et al. and (D) Garnett et al. BD-L, BRCA1 Deficient-Like.