Figure 2
From: Clinical development of mTOR inhibitors in breast cancer
mTOR-dependent pathways and inhibitors. Mammalian target of rapamycin (mTOR) depends on two pathways: the phosphatidylinositol-3-kinase (PI3K)-dependent pathway and the 5′ adenosine monophosphate-activated protein kinase (AMPK)-dependent pathway (the energy pathway). Various inhibitors have been reported to act on one kinase in each of the pathways. LKB1, liver kinase B1; mTORC, mTOR complex; TSC1/2, tuberous sclerosis 1/2.