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Figure 1 | Breast Cancer Research

Figure 1

From: Identification and characterization of locus-specific methylation patterns within novel loci undergoing hypermethylation during breast cancer pathogenesis

Figure 1

Examples of the classes of methylation-sensitive high-resolution melting profiles observed in the case sample material. Standards: 100% methylated (red), 10% methylated in a background of unmethylated template (blue), 1% methylated (yellow) and unmethylated (green). Sample with a representative methylation-sensitive high-resolution melting profile is shown in black. Melting peaks were generated by taking the negative derivative (d) of the melting curve data divided by the derivative with respect to time -(d/dT). (A) Fully methylated sample (BC008699 assay) (B) Sample displaying the presence of both methylated and unmethylated alleles (HOXB13 assay). (C) Heterogeneously methylated sample (SIX6 assay). (D) Sample with no signs of methylation (CA10 assay).

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Breast Cancer Research

ISSN: 1465-542X

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