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Figure 3 | Breast Cancer Research

Figure 3

From: Inducible and coupled expression of the polyomavirus middle T antigen and Cre recombinase in transgenic mice: an in vivo model for synthetic viability in mammary tumour progression

Figure 3

Cre recombinase expression and activity are uniform in the epithelium of rtTA/MIC mammary tumours. X-gal staining (blue) of mammary tumour sections from rtTA/MIC animals carrying the Cre recombinase-activated β-galactosidase reporter transgene (GTRosa). Negative controls include MMTV-PyV mT mammary tumours with either GTRosa (PyV mT/GTRosa) or MMTV-Cre recombinase transgenes (PyV mT/Cre recombinase). An MMTV-PyV mT mammary tumour with both transgenes (PyV mT/Cre recombinase/GTRosa) was used as a positive control. Samples were counterstained with nuclear fast red (pink). (Scale bar: 500 μm).

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Breast Cancer Research

ISSN: 1465-542X

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