Figure 5

FFPE cohort outcome analyzed by recursive partitioning ( rpart ) using clinical parameters and the five-gene ICS. The rpart analysis selected nodal status and Integrated Cytokine Score (ICS) in a conditional model which best predicts DR outcome. (A) rpart tree, (B) Kaplan-Meier curves of rpart tree branches. Color of curves corresponds to terminal branch color: dark blue = LN-, ICS Low; skyblue = LN- ICS High; red = LN+, (C) Kaplan-Meier curves of the LN-, ICS Low group (dark blue) further stratified by grade (I/II = dashed line, III = dotted line), (D) Kaplan-Meier curves of the LN + rpart group (red) stratified by ICS at an optimal threshold, ICS = -0.4 (Low ICS = dashed line, High ICS = dotted line).