Volume 15 Supplement 1
PB.23: Effect of detector type on cancer detection in digital mammography
© Mackenzie et al.; licensee BioMed Central Ltd. 2013
Published: 8 November 2013
This work measured the effect that image quality associated with different detectors has on cancer detection in mammography using a novel method for changing the appearance of images.
A set of 270 mammography cases (one view, both breasts) was acquired using five Hologic Selenias and two Hologic Dimensions X-ray units: 80 normal, 80 with simulated inserted subtle calcification clusters, 80 with subtle real noncalcification malignant lesions and 30 with benign lesions (biopsy proven). These 270 cases (Arm 1) were converted to appear as if they had been acquired on two other imaging systems: needle image plate computed radiography (CR) (Arm 2) and powder phosphor CR (Arm 3). Three experienced mammography readers marked the location of suspected cancers in the images and classified whether each lesion would require further investigation and the confidence in that decision. Performance was calculated as the area under curve (AUC) of the alternative free-response receiver operating characteristic curve.
The AUCs of Arms 1 to 3 were 0.750, 0.707 and 0.648 for calcification clusters and 0.744, 0.722 and 0.694 for noncalcification cancers. The differences between all of the arms for calcification clusters were statistically significant (P < 0.05). No significant differences were found for noncalcification lesions. The percentage of correctly marked lesions that were classified as recalled lesions dropped from 58% to 39% (calcifications) and from 72% to 62% (non-calcifications) between Arms 1 and 3.
Detector type has a significant impact on the detection and recall of calcification clusters but not noncalcification cancers.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.