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Table 1 Baseline demographics

From: Phase I trial of the oral PARP inhibitor olaparib in combination with paclitaxel for first- or second-line treatment of patients with metastatic triple-negative breast cancer

 

Cohort 1

Cohort 2

Overall

 

(n = 9)

(n = 10)

(n = 19)

Mean age, years (range)

50.0 (36 to 71)

50.7 (38 to 67)

50.4 (36 to 71)

ECOG status, n

   

0/1/2

8/1/0

5/5/0

13/6/0

Previous chemotherapy regimens, n (%)

   

 Any adjuvant regimen

5 (56)

9 (90)

14 (74)

 Taxanea

7 (78)

8 (80)

15 (79)

  First-line setting

2 (22)

0

2 (11)

  Adjuvant setting

2 (22)

6 (60)

8 (42)

  Neo-adjuvant setting

3 (33)

1 (10)

4 (21)

  Metastatic setting

0

2 (20)

2 (11)

 Anthracycline

6 (67)

6 (60)

12 (63)

 Capecitabine

1 (11)

0

1 (5)

  1. ECOG, Eastern Cooperative Group.
  2. aOne patient in cohort 2 had previously received taxane chemotherapy in both adjuvant and metastatic settings.