Table 1 Summary of association results of the genome-wide association study
From: A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients
|  |  |  |  |   ADRb |   Non-ADRc | RAF | Pvalue |  |  | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CHR | SNP | Gene | Allele 1/2 (risk) | 11 | 12 | 22 | 11 | 12 | 22 | ADR | Non-ADR | Allelic | Dominant | Recessive | ORa | 95% CI |
2 | rs3820706 | CACNB4 | A/G (G) | 18 | 169 | 116 | 167 | 421 | 291 | 0.66 | 0.57 | 8.26E-05 | 1.07E-01 | 8.13E-09 | 3.71 | (2.24-6.15) |
2 | rs6725180 | CACNB4 | A/C (C) | 17 | 152 | 134 | 135 | 429 | 316 | 0.69 | 0.60 | 7.90E-05 | 1.11E-02 | 3.84E-06 | 3.05 | (1.81-5.14) |
8 | rs16908658 | FAM135B | G/A (G) | 30 | 93 | 180 | 23 | 286 | 571 | 0.25 | 0.19 | 1.07E-03 | 9.68E-02 | 9.93E-07 | 4.09 | (2.34-7.17) |
10 | rs7476422 | PCDH15 | T/G (G) | 4 | 47 | 252 | 34 | 245 | 601 | 0.91 | 0.82 | 1.20E-07 | 3.77E-07 | 3.58E-02 | 2.17 | (1.60-2.93) |
10 | rs857373 | PCDH15 | G/A (A) | 5 | 55 | 243 | 43 | 255 | 581 | 0.89 | 0.81 | 5.16E-07 | 3.15E-06 | 1.11E-02 | 2.00 | (1.51-2.66) |
10 | rs857392 | PCDH15 | G/A (A) | 5 | 55 | 243 | 42 | 252 | 584 | 0.89 | 0.81 | 9.08E-07 | 5.95E-06 | 1.60E-02 | 1.97 | (1.48-2.62) |
10 | rs1319836 | PCDH15 | C/T (T) | 5 | 55 | 243 | 42 | 254 | 583 | 0.89 | 0.81 | 9.10E-07 | 4.34E-06 | 1.60E-02 | 1.98 | (1.49-2.63) |
10 | rs7919725 | PCDH15 | A/G (G) | 5 | 56 | 242 | 42 | 256 | 580 | 0.89 | 0.81 | 9.94E-07 | 4.68E-06 | 1.60E-02 | 1.97 | (1.48-2.60) |
10 | rs857369 | PCDH15 | T/C (C) | 1 | 32 | 270 | 18 | 178 | 684 | 0.94 | 0.88 | 2.29E-06 | 7.25E-06 | 5.87E-02 | 2.33 | (1.60-3.39) |
10 | rs9416306 | PCDH15 | G/T (T) | 1 | 32 | 270 | 18 | 178 | 682 | 0.94 | 0.88 | 2.29E-06 | 7.13E-06 | 5.88E-02 | 2.34 | (1.61-3.39) |
10 | rs1219862 | PCDH15 | C/T (T) | 2 | 31 | 270 | 17 | 182 | 681 | 0.94 | 0.88 | 2.73E-06 | 5.08E-06 | 1.85E-01 | 2.28 | (1.58-3.30) |
13 | rs7318267 | FARP1 | C/T (T) | 11 | 149 | 143 | 108 | 387 | 385 | 0.72 | 0.66 | 6.69E-03 | 3.15E-01 | 4.09E-06 | 3.71 | (1.97-7.01) |
13 | rs2282048 | FARP1 | T/C (C) | 11 | 148 | 144 | 107 | 387 | 386 | 0.72 | 0.66 | 5.72E-03 | 2.84E-01 | 6.24E-06 | 3.68 | (1.95-6.93) |
17 | rs1530357 | LOC100506974 | A/G (A) | 57 | 170 | 76 | 114 | 417 | 349 | 0.47 | 0.37 | 1.11E-05 | 4.29E-06 | 1.39E-02 | 1.96 | (1.45-2.63) |
17 | rs1530361 | LOC100506974 | A/G (A) | 53 | 165 | 85 | 99 | 408 | 372 | 0.45 | 0.35 | 8.83E-06 | 1.12E-05 | 7.04E-03 | 1.54 | (1.27-1.86) |
19 | rs11666971 | LASS4 | G/A (G) | 46 | 119 | 138 | 56 | 379 | 445 | 0.35 | 0.28 | 1.64E-03 | 1.43E-01 | 8.13E-06 | 2.63 | (1.74-3.96) |