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Table 2 Odds ratios (ORs) and 95% confidence intervals (CIs) for breast cancer risk by tumor subtype associated with BI-RADS-measured mammographic density

From: Association between mammographic density and basal-like and luminal A breast cancer subtypes

  Number of subjects Cases versus controls   Triple-negatives versus controls
  Controls Cases Model 1a Model 2b TN cases, n Model 1 Model 2
    OR (95% CI) OR (95% CI)   OR (95% CI) OR (95% CI)
Almost entirely fat 25 13 1.00 (Referent) 0.48 (0.22, 1.08) 1 1.00 (Referent) 0.17 (0.02, 1.43)
Scattered fibroglandular densities 197 183 2.07 (0.93, 4.59) 1.00 (Referent) 31 5.96 (0.70, 50.64) 1.00 (Referent)
Heterogeneously dense 253 232 2.06 (0.92, 4.60) 1.00 (0.7, 1.35) 40 5.83 (0.68, 50.04) 0.98 (0.5, -1.75)
Extremely dense 53 63 2.45 (0.99, 6.09) 1.19 (0.72, 1.95) 12 7.13 (0.74, 68.90) 1.20 (0.49, 2.90)
    Ptrend = 0.24c   Ptrend = 0.31
    Basal-like versus controls   Luminal A versus controls
  BL cases, n   Model 1 Model 2 LA cases, n Model 1 Model 2
    OR (95% CI) OR (95% CI)   OR (95% CI) OR (95% CI)
Almost entirely fat 1   1.00 (Referent) 0.29 (0.03, 2.51) 4 1.00 (Referent) 0.49 (0.15, 1.59)
Scattered fibroglandular densities 19   3.45 (0.40, 29.90) 1.00 (Referent) 69 2.03 (0.63, 6.59) 1.00 (Referent)
Heterogeneously dense 22   3.03 (0.34, 26.67) 0.88 (0.43, 1.80) 86 2.09 (0.64, 6.79) 1.03 (0.68, 1.56)
Extremely dense 6   3.58 (0.34, 37.97) 1.04 (0.34, 3.17) 22 1.98 (0.54, 7.34) 0.98 (0.50, 1.92)
    Ptrend = 0.67   Ptrend = 0.60
  1. aModel 1 is adjusted for age, race, body mass index, menopausal status, family history of breast cancer, age at menarche, use of hormone therapy, and parity and age at first full-term pregnancy combined, where BI-RADS category 1 (almost entirely fat) is the referent group; bModel 2 is adjusted for the same variables as Model 1 but BI-RADS category 2 (scattered fibroglandular densities) is the referent group; cP-value for trend test is based on the likelihood ratio test statistic and is two-sided. The same ordinal model was fit to assess the P-value for trend of Model 1 and Model 2. BI-RADS, Breast Imaging Reporting and Data System; TN, triple-negative; BL, basal-like; LA, luminal-A; n, number of subjects.
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