PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer

Breast Cancer Research

Table 3 Correlation of p4EBP1, pS6 and pAKT immunohistochemistry with BRCA status and clinicopathological factors

	4EBP1						pS6			pAKT
	Cytoplasmic			Nuclear			Cytoplasmic			Nuclear
	Present	Absent	P -value	Present	Absent	P -value	High	Low	P -value	High	Low	P -value
PIK3CA Mutation	0	6		0	6		5	1		2	4
PIK3CA Wild-Type	31	19	0.006	29	21	0.009	16	34	0.024	19	31	1.000
Carrier mutation status
BRCA1	1	2	0.581	1	2	0.605	1	2	1.000	0	3	0.284
BRCA2	15	10	0.596	17	8	0.035	9	16	0.582	10	15	0.786
BRCAX	15	13	0.456	11	19	0.018	11	17	1.000	11	17	1.000
Age - mean (years)	60.3	64.5	0.240	59.1	65.3	0.078	63.4	61.4	0.503	62.0	62.2	0.940
Primary tumour size (mm)	20.3	17.2	0.169	19.5	18.3	0.589	17.21	20.03	0.312	20.05	18.25	0.437
Histological type
Invasive carcinoma - no special type (IC - NST)	21	19	0.563	22	19	0.766	13	28	0.212	15	26	1.000
IC-NST with micropapillary areas	6	3	0.716	3	6	0.288	6	3	0.066	3	6	1.000
Invasive Papillary Carcinoma	2	2	1.000	3	1	0.612	2	2	0.626	2	2	0.626
Invasive Lobular Carcinoma	2	1	1.000	1	1	1.000	0	2	0.523	1	1	1.000
Tumour Grade
1	2	1	1.000	2	1	1.000	2	1	0.549	1	2	1.000
2	16	13	1.000	16	13	0.789	9	20	0.409	11	18	1.000
3	13	11	1.000	11	13	0.590	10	14	0.591	9	15	1.000
LVI	40.7%	36.0%	0.781	28.0%	48.2%	0.163	31.8%	43.3%	0.565	33.3%	41.9%	0.780
PNI	51.7%	45.8%	0.575	40.7%	57.6%	0.436	36.4%	58.1%	0.166	33.3%	59.0%	0.093
Intrinsic subtype
Luminal	26	24	0.210	24	26	0.195	17	33	0.183	20	30	0.393
HER2	4	1	0.367	4	1	0.353	3	2	0.352	1	4	0.640
Basal	1	0	1.000	1	0	1.000	1	0	0.375	0	1	1.000
Null	0	0	1.000	0	0	1.000	0	0	1.000	0	0	1.000

ISSN: 1465-542X