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Table 3 Correlation of p4EBP1, pS6 and pAKT immunohistochemistry with BRCA status and clinicopathological factors

From: PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer

  4EBP1 pS6 pAKT
  Cytoplasmic Nuclear Cytoplasmic Nuclear
  Present Absent P -value Present Absent P -value High Low P -value High Low P -value
PIK3CA Mutation 0 6   0 6   5 1   2 4  
PIK3CA Wild-Type 31 19 0.006 29 21 0.009 16 34 0.024 19 31 1.000
Carrier mutation status             
   BRCA1 1 2 0.581 1 2 0.605 1 2 1.000 0 3 0.284
   BRCA2 15 10 0.596 17 8 0.035 9 16 0.582 10 15 0.786
   BRCAX 15 13 0.456 11 19 0.018 11 17 1.000 11 17 1.000
Age - mean (years) 60.3 64.5 0.240 59.1 65.3 0.078 63.4 61.4 0.503 62.0 62.2 0.940
Primary tumour size (mm) 20.3 17.2 0.169 19.5 18.3 0.589 17.21 20.03 0.312 20.05 18.25 0.437
Histological type             
   Invasive carcinoma - no special type (IC - NST) 21 19 0.563 22 19 0.766 13 28 0.212 15 26 1.000
   IC-NST with micropapillary areas 6 3 0.716 3 6 0.288 6 3 0.066 3 6 1.000
   Invasive Papillary Carcinoma 2 2 1.000 3 1 0.612 2 2 0.626 2 2 0.626
   Invasive Lobular Carcinoma 2 1 1.000 1 1 1.000 0 2 0.523 1 1 1.000
Tumour Grade             
   1 2 1 1.000 2 1 1.000 2 1 0.549 1 2 1.000
   2 16 13 1.000 16 13 0.789 9 20 0.409 11 18 1.000
   3 13 11 1.000 11 13 0.590 10 14 0.591 9 15 1.000
LVI 40.7% 36.0% 0.781 28.0% 48.2% 0.163 31.8% 43.3% 0.565 33.3% 41.9% 0.780
PNI 51.7% 45.8% 0.575 40.7% 57.6% 0.436 36.4% 58.1% 0.166 33.3% 59.0% 0.093
Intrinsic subtype             
   Luminal 26 24 0.210 24 26 0.195 17 33 0.183 20 30 0.393
   HER2 4 1 0.367 4 1 0.353 3 2 0.352 1 4 0.640
   Basal 1 0 1.000 1 0 1.000 1 0 0.375 0 1 1.000
   Null 0 0 1.000 0 0 1.000 0 0 1.000 0 0 1.000