Figure 2From: Progestin effects on cell proliferation pathways in the postmenopausal mammary glandHormone therapy effects on gene markers related to mammary gland proliferation. (a) markers included cell proliferation (MKI67) and epithelial density (KRT19) and genes involved in the following signaling pathways; (b) STAT5; (c) EGFR; and (d) TGF-beta. mRNA levels were determined by quantitative PCR. Vertical lines indicate 90% confidence interval. Letters indicate significant differences compared with control (P < 0.05a, P < 0.01b, P < 0.001c) and conjugated equine estrogens plus medroxyprogesterone acetate (CEE + MPA), (P < 0.01d, P < 0.001e) groups.Back to article page