BreastMark: An Integrated Approach to Mining Publicly Available Transcriptomic Datasets Relating to Breast Cancer Outcome

Table 5 Receptor tyrosine kinases associated with poor survival in the basal molecular subtype

Gene name	Gene description	Survival end point	Molecular classifier	Expression cut-off	Hazard ratio	P-value	Number
EPHA5	EPH receptor A5	OS	SSP2003	median	2.03	3.36e-03	233
		DFS	SSP2006	median	1.37	0.05	422
		OS	SSP2006	median	1.59	0.05	271
FGFR1	fibroblast growth factor receptor 1	DFS	SSP2006	High	1.43	0.02	465
		DFS	PAM50	High	1.36	0.05	408
FGFR3	fibroblast growth factor receptor 3	OS	SSP2003	High	1.63	0.04	273
		OS	SSP2003	Median	1.53	0.04	273
		OS	SSP2006	Median	1.62	0.01	323
		OS	PAM50	Median	1.54	0.03	293
VEGFR1	vascular endothelial growth factor receptor 1	DDFS	SSP2003	Low	1.84	0.05	320
		OS	SSP2003	Median	1.53	0.05	249
		OS	SSP2006	High	1.76	7.40e-03	284
		OS	SSP2006	Median	1.69	9.50e-03	284
		DDFS	SSP2006	Low	1.85	0.03	378
		DDFS	PAM50	Low	2.07	0.02	365
		OS	PAM50	High	1.61	0.04	261
		OS	PAM50	Median	1.61	0.03	261
PDGFRβ	platelet-derived growth factor receptor, beta polypeptide	DDFS	SSP2003	Median	1.88	1.64e-03	341
		DDFS	SSP2003	High	2.26	9.34e-04	341
		OS	SSP2003	Median	1.55	0.05	273
		DFS	SSP2006	Median	1.37	0.02	474
		OS	SSP2006	Median	1.72	5.84e-03	323
		OS	SSP2006	High	2.12	1.26e-03	323
		DDFS	SSP2006	High	1.76	0.01	423
		DFS	SSP2006	High	1.50	0.01	474
		DDFS	PAM50	Median	1.81	8.58e-04	393
		DDFS	PAM50	High	1.86	6.33e-03	393
		OS	PAM50	High	1.94	7.27e-03	293
		DFS	PAM50	High	1.58	7.56e-03	419
		DFS	PAM50	Median	1.38	0.02	419
		DDFS	PAM50	Low	1.45	0.04	393
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	OS	SSP2003	Median	1.63	0.02	273
		OS	SSP2006	Median	1.70	4.82e-03	323
		OS	PAM50	Median	1.56	0.03	293

DFS, disease-free survival; DDFS, distant disease-free survival; OS, overall survival.

ISSN: 1465-542X